Large-Scale Synthesis of Man9GlcNAc2 High-Mannose Glycan and the Effect of the Glycan Core on Multivalent Recognition by HIV Antibody 2G12.
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DOI: 10.1021/acsinfecdis.2c00442
Abstract: Access to homogeneous high-mannose glycans in high-mg quantities is necessary for carbohydrate-based HIV vaccine development research. We have used directed evolution to design highly antigenic oligomannose clusters that are recognized in low-nM affinity by HIV… read more here.
Keywords: hiv; large scale; synthesis man9glcnac2; synthesis ... See more keywords