Biomimetic Synthesis of the Marine-Derived Thioalkaloids Dassonmycins A and B.
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DOI: 10.1021/acs.orglett.4c03937
Abstract: A biomimetic synthesis of the marine thioalkaloids dassonmycins A and B is reported. The synthesis features a chemoselective reduction of a diketopiperazine to form a 2-piperazinone, which undergoes heteroannulation with naphthoquinone to yield dassonmycin A.… read more here.
Keywords: marine derived; thioalkaloids dassonmycins; synthesis marine; synthesis ... See more keywords
Concise synthesis of marine natural products smenodiol and (−)-pelorol
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DOI: 10.1080/14786419.2021.2023871
Abstract: Abstract A facile synthesis of marine natural product smenodiol has been achieved in 23.2% overall yield within 8 steps from readily available starting materials, which facilitates a concise synthesis of the marine natural product (−)-pelorol… read more here.
Keywords: marine natural; pelorol; concise synthesis; natural product ... See more keywords
Recent Advances in the Chemical Synthesis of Marine Acidic Carbohydrates
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DOI: 10.2174/1385272824999201230120805
Abstract: The ocean supplies abundant active compounds, including small organic molecules, proteins, lipids, and carbohydrates, with diverse biological functions. The high-value transformation of marine carbohydrates primarily refers to their pharmaceutical, food, and cosmetic applications. However, it… read more here.
Keywords: marine acidic; acidic carbohydrates; marine; synthesis marine ... See more keywords
Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances
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DOI: 10.3390/md19040208
Abstract: The sea covers more than 70% of Earth's surface and contains more than 300,000 organisms with huge biodiversity [...]. read more here.
Keywords: products molecules; natural products; marine natural; synthesis marine ... See more keywords
Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents
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DOI: 10.3390/md20030158
Abstract: In this paper, eight new galaxamide analogues (Z-1~Z-8) were synthesized and evaluated for their cytotoxic activities against five cancer cell lines, MCF-7, MD-MBA-231, HepG2, Hela, and A549, using MTT assays. The modified analogue Z-6 displayed… read more here.
Keywords: analogues potential; cyclopeptide galaxamide; galaxamide analogues; galaxamide ... See more keywords