Design, synthesis and mechanistic studies of novel imidazo[1,2-a]pyridines as anticancer agents.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.2139/ssrn.4063470
Abstract: Herein, the design, synthesis and mechanistic study of five series of imidazo[1,2-a]pyridines 8a-d, 9a-f, 11a-c, 12a-d and 14a-d as anticancer agents were discussed. The cytotoxicity of imidazo[1,2-a]pyridine derivatives was screened against NCI 60 cancer cell… read more here.
Keywords: design synthesis; cell; imidazo pyridines; leukemia 562 ... See more keywords
Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors
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DOI: 10.3390/antibiotics11081126
Abstract: Methionine aminopeptidases (MetAPs) are attractive drug targets due to their essential role in eukaryotes as well as prokaryotic cells. In this study, biochemical assays were performed on newly synthesized Isatin-pyrazole hydrazones (PS1–14) to identify potent… read more here.
Keywords: design synthesis; ps9 inhibited; selective bacterial; bacterial strains ... See more keywords