Functionalized Polyhydroquinolines from Amino Acids Using a Key One-Pot Cyclization Cascade and Application to the Synthesis of (±)-Δ7-Mesembrenone.
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DOI: 10.1021/acs.orglett.1c03323
Abstract: Substituted polyhydroquinolines are ubiquitous skeletal cores found in drugs and bioactive natural products. As a new route to access this motif, we successfully developed a one-pot cyclization cascade with high chemocontrol and diastereoselectivity. The sequence… read more here.
Keywords: amino acids; synthesis mesembrenone; functionalized polyhydroquinolines; cyclization cascade ... See more keywords