Chemoenzymatic Synthesis of 5-Methylpsilocybin: A Tryptamine with Potential Psychedelic Activity.
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DOI: 10.1021/acs.jnatprod.1c00087
Abstract: A novel analogue of psilocybin was produced by hybrid chemoenzymatic synthesis in sufficient quantity to enable bioassay. Utilizing purified 4-hydroxytryptamine kinase from Psilocybe cubensis, chemically synthesized 5-methylpsilocin (2) was enzymatically phosphorylated to provide 5-methylpsilocybin (1).… read more here.
Keywords: chemoenzymatic synthesis; activity; synthesis methylpsilocybin; methylpsilocybin tryptamine ... See more keywords