Design, synthesis, and molecular docking study of benzothiazolotriazine derivatives for anticonvulsant potential
Sign Up to like & getrecommendations! Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800154
Abstract: A series of newer benzothiazolotriazine derivatives (4a–k) was designed, synthesized, and characterized as anticonvulsant agents against the two classically used MES and scPTZ animal models. The synthesized derivatives were tested in vivo in both the… read more here.
Keywords: design synthesis; benzothiazolotriazine derivatives; study; animal models ... See more keywords
Design, synthesis, and molecular docking study of novel quinoline‐based bis‐chalcones as potential antitumor agents
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100094
Abstract: A novel series of quinoline‐based symmetrical and unsymmetrical bis‐chalcones was synthesized via a Claisen–Schmidt condensation reaction between 3‐formyl‐quinoline/quinolone derivatives with acetone or arylidene acetones, respectively, by using KOH/MeOH/H2O as a reaction medium. Twelve of the… read more here.
Keywords: design synthesis; bis chalcones; quinoline; bis ... See more keywords
MULTICOMPONENT SYNTHESIS AND MOLECULAR STRUCTURE OF 3-AMINO-2-AROYL(ALKOXYCARBONYL, ARYLCARBAMOYL)-4-ARYL(HETARYL)- 5-ARYLCARBAMOYL-6-METHYLTHIENO[2,3- b ]PYRIDINES
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/4976
Abstract: Разработан новый эффективный метод синтеза функционализированных тиено[2,3- b ]пиридинов многокомпонентной конденсацией ароматических и гетероароматических альдегидов, цианотиоацетамида, ацетоацетанилидов и метиленактивных алкилирующих реагентов. Строение 3-амино-2-бензоил-6-метил- N -фенил-4-(фуран-2-ил)тиено[2,3- b ]пиридин-5-карбоксамида, 3-амино- N 2 -(4-бромфенил)-6-метил-4-(3-метилтиофен-2-ил)- N 5 -(4-хлорфенил)тиено[2,3- b… read more here.
Keywords: amino aroyl; molecular structure; multicomponent synthesis; structure amino ... See more keywords
Design, synthesis, molecular modeling, and ADMET studies of some pyrazoline derivatives as shikimate kinase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2081-9
Abstract: A series of pyrazoline derivatives were synthesized and their structures have been characterized by IR, 1H NMR, 13C NMR, mass spectral and elemental analysis. The novel compounds were designed as Mycobacterium tuberculosis shikimate kinase (MtSK)… read more here.
Keywords: design synthesis; molecular modeling; pyrazoline derivatives; shikimate kinase ... See more keywords
Synthesis, molecular docking and cholinesterase inhibitory activity of hydroxylated 2-phenylbenzofuran derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.11.043
Abstract: We have designed, synthesized and evaluated a series of hydroxylated 2-phenylbenzofuran derivatives as potential cholinesterase inhibitors. Starting from a series of 2-phenylbenzofurans previously published, in this paper we present a complete synthesis and the influence… read more here.
Keywords: phenylbenzofuran derivatives; hydroxylated phenylbenzofuran; inhibitory activity; activity ... See more keywords
Synthesis, molecular docking studies, and antimicrobial evaluation of new structurally diverse ureas.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.03.024
Abstract: A series of new urea derivatives (3a-p) have been synthesized from readily available isocyanates and amines in good to high yields. All synthesized compounds were fully characterized using 1H NMR, 13C NMR, IR, and mass… read more here.
Keywords: docking studies; antimicrobial evaluation; evaluation new; studies antimicrobial ... See more keywords
Synthesis, molecular docking and molecular dynamics studies of novel tacrine-carbamate derivatives as potent cholinesterase inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105225
Abstract: In the present study, new tacrine derivatives containing carbamate group were synthesized and their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition activities were evaluated. All synthesized compounds inhibited both cholinesterases at nanomolar level. Among them, ((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl(3-nitrophenyl)… read more here.
Keywords: synthesized compounds; buche; carbamate derivatives; carbamate ... See more keywords
Advances in the synthesis, molecular architectures and potential applications of gemini surfactants.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in colloid and interface science"
DOI: 10.1016/j.cis.2017.07.032
Abstract: Gemini surfactants have been the subject of intensive scrutiny by virtue of their unique combination of physical and chemical properties and being used in ordinary household objects to multifarious industrial processes. In this review, we… read more here.
Keywords: applications gemini; advances synthesis; gemini surfactants; potential applications ... See more keywords
Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.005
Abstract: In the last two decades, trans-sialidase of Trypanosoma cruzi (TcTS) has been an important pharmacological target for developing new anti-Chagas agents. In a continuous effort to discover new potential TcTS inhibitors, 3-amino-3-arylpropionic acid derivatives (series… read more here.
Keywords: phthaloyl derivatives; trans sialidase; novel phthaloyl; trypanosoma cruzi ... See more keywords
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.069
Abstract: This paper describes the rational development of a series of novel spiroindoline derivatives endowed with selective inhibitory activity on the HDAC6 isoform. A convenient multicomponent one-pot protocol was applied for the assembly of the desired… read more here.
Keywords: inhibitors synthesis; hdac inhibitors; novel spiroindoline; spiroindoline hdac ... See more keywords
Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e04958
Abstract: Twenty-three new series of toluene-sulfonamide dipeptide derivatives were synthesized and screened for antiplasmodial and antioxidant potencies. Many of the derivatives were active against Plasmodium falciparum with IC50 ranging from 3.20 – 9.10 μM. The ability… read more here.
Keywords: antioxidant activities; activities new; antiplasmodial antioxidant; docking antiplasmodial ... See more keywords