Synthesis of natural phaeosphaeride A and semi-natural phaeosphaeride B derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2017.09.020
Abstract: 6-O-Acylated phaeosphaeride A and phaeosphaeride B in reaction with secondary cyclic amines undergo stereospecific replacement of acyloxy group by pharmacophoric amino moiety. In case of chloroacetoxy derivative, chlorine displacement by such amines proceeds in the… read more here.
Keywords: semi natural; phaeosphaeride; phaeosphaeride semi; synthesis natural ... See more keywords
In Situ Synthesis of Natural Antioxidase Mimics for Catalytic Anti-Inflammatory Treatments: Rheumatoid Arthritis as an Example.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c09993
Abstract: Mimicking the coordination geometry of the active metal sites of natural enzymes is an efficient strategy in designing therapeutic chemicals with enzymelike in vivo reaction thermodynamics and kinetics. In this study, this chemical concept has… read more here.
Keywords: rheumatoid arthritis; situ synthesis; synthesis natural; natural antioxidase ... See more keywords
Ketones as strategic building blocks for the synthesis of natural product-inspired compounds.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d2cs00101b
Abstract: Natural product-inspired compound collections serve as excellent sources for the identification of new bioactive compounds to treat disease. However, such compounds must necessarily be more structurally-enriched than traditional screening compounds, therefore inventive synthetic strategies and… read more here.
Keywords: product inspired; inspired compounds; product; building blocks ... See more keywords
The Untold Journey of Total Synthesis of Natural Products
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DOI: 10.1055/a-2010-7874
Abstract: This personal Account presents the developments of two synthetic strategies (Phenol Oxidative Dearomatization, POD; and Furan Oxidative dearomatization, FOD) for total synthesis of natural products. The POD program was originally derived from our first total… read more here.
Keywords: natural products; synthesis; journey total; untold journey ... See more keywords
Synthesis of Natural Products, Carbocycles, and Heterocycles by Hauser–Kraus Annulation
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DOI: 10.1055/a-2068-7126
Abstract: In this account, we have summarized the recent developments in Hauser-Kraus (H-K) annulation with respect to the synthesis of natural products, other functionalized and fused carbocycles and spiro-heterocycles. Although classical H-K annulation is between a… read more here.
Keywords: natural products; annulation; synthesis natural; hauser kraus ... See more keywords
Application of Dess-Martin oxidation in total synthesis of natural products.
Sign Up to like & getrecommendations! Published in 2020 at "Current organic synthesis"
DOI: 10.2174/1570179417666200917102634
Abstract: Dess-Martin periodinane (DMP), is a commercially available chemical, frequently being utilized as a mild oxidative agent for the selective oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones, respectively. DMP shows several… read more here.
Keywords: natural products; total synthesis; synthesis natural; dess martin ... See more keywords
Total Synthesis of Natural Terpenoids Enabled by Cobalt Catalysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.941184
Abstract: Transition metal catalysis plays an essential role in the total synthesis of natural products. Cobalt-mediated asymmetric catalysis has successfully been used as a primary or a secondary step in the total synthesis of natural products,… read more here.
Keywords: natural terpenoids; catalysis; natural products; synthesis natural ... See more keywords
Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review
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DOI: 10.3390/molecules27206953
Abstract: The Mitsunobu reaction plays a vital part in organic chemistry due to its wide synthetic applications. It is considered as a significant reaction for the interconversion of one functional group (alcohol) to another (ester) in… read more here.
Keywords: reaction; natural products; mitsunobu reaction; synthesis natural ... See more keywords
Biomimetic Approaches to the Synthesis of Natural Disesquiterpenoids: An Update
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DOI: 10.3390/plants10040677
Abstract: Natural disesquiterpenoids represent a small group of secondary metabolites characterized by complex molecular scaffolds and interesting pharmacological profiles. In the last decade, more than 400 new disesquiterpenoids have been discovered and fully characterized, pointing out… read more here.
Keywords: biomimetic approaches; approaches synthesis; natural disesquiterpenoids; synthesis natural ... See more keywords