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Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2003-x
Abstract: A series of 5,6-diaryl-1,2,4-triazine-3-thioacetate derivatives 3a–f, 8a–d and their regioisomer 8e were synthesized. Neuroprotective activity of compounds was assessed against H2O2 and β-amyloid-induced toxicity in PC12 and SH-SY5Y cells respectively. Surprisingly, ethyl 2-(5-(4-chlorophenyl)-6-(4-methoxyphenyl)-3-thioxo-1,2,4-triazin-2(3H)-yl)acetate (8e) was…
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Keywords:
activity novel;
synthesis neuroprotective;
h2o2 induced;
neuroprotective activity ... See more keywords
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Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16030355
Abstract: In this investigation, a number of phenoxyindole derivatives were designed, synthesized, and tested for their neuroprotective ability on SK-N-SH cells against Aβ42-induced cell death and biologically specific activities involved in anti-Aβ aggregation, anti-AChE, and antioxidant…
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Keywords:
design synthesis;
aggregation;
compound;
phenoxyindole derivatives ... See more keywords