Synthesis of new N‐(3‐oxo‐1‐thia‐4‐azaspiro[4.5]decan‐4‐yl)pyridine‐3‐carboxamide derivatives and evaluation of their anti‐influenza virus and antitubercular activities
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200224
Abstract: We here report the synthesis, structural characterization, and evaluation of the antiviral and antitubercular activities of a novel series of hybrid spirothiazolidinone derivatives (2a–f and 3a–f) containing the nicotinohydrazide moiety, which is an isomer form… read more here.
Keywords: antitubercular activities; oxo thia; virus; new oxo ... See more keywords
Highly Stereoselective Synthesis of New Aziridines via Baldwin Rearrangement and Their Potential Biological Activities
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DOI: 10.1002/jhet.2548
Abstract: An atom-economical conversion of N-substituted isoxazoline derivatives to new N-substituted aziridines has been described using microwave irradiation through Baldwin rearrangement. N-substituted isoxazoline derivatives have been synthesized using a variety of nitrones and alkynes via 1,3-dipolar… read more here.
Keywords: highly stereoselective; synthesis new; stereoselective synthesis; baldwin rearrangement ... See more keywords
Synthesis of New Imino Containing Tetrahydrochromeno[2,3-d]pyrimidines
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DOI: 10.1002/jhet.2729
Abstract: Some new derivatives of 3,5-diaryl-4-imino-5,7,8,9-tetrahydro-3H-chromeno[2,3-d]pyrimidine have been prepared through a condensation reaction of 2-amino-4-aryl-3-cyano-5,6,7,8-tetrahydrobenzo[b]pyrans with triethyl orthoformate in boiling acetic anhydride followed by cyclization with primary aryl amines in the presence of a few drops… read more here.
Keywords: containing tetrahydrochromeno; synthesis new; imino containing; imino ... See more keywords
Design and Synthesis of New 1,3,5‐Trisubstituted Triazines for the Treatment of Cancer and Inflammation
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DOI: 10.1002/open.201800136
Abstract: Abstract Low‐molecular‐weight synthetic molecules 1 with the general 2‐(fluorophenylamino)‐4,6‐disubstituted 1,3,5‐triazine structure and showing anti‐inflammatory and anticancer activities were explored. Structure–activity relationship studies demonstrated the importance of the aminopentyl chain, the 3‐ or 4‐fluorophenylaniline component, and… read more here.
Keywords: design synthesis; synthesis new; treatment; inflammation ... See more keywords
SYNTHESIS OF NEW 4-AMINO-SUBSTITUTED 7-IMINOPYRIDO[2,3- d ]PYRIMIDINES
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DOI: 10.1007/3600
Abstract: The reaction of 4,6-dichloropyrimidine-5-carbaldehyde with cyanomethyltriphenylphosphonium chloride gave (2 Е )-3-(4,6-dichloropyrimidin-5yl)acrylonitrile, which was further used for the preparation of 4,6-diamino-substituted pyrimidinylacrylonitrile derivatives, capable of intramolecular cyclization with the formation of new 4-amino-substituted 7-iminopyrido[2,3- d ]pyrimidines.… read more here.
Keywords: amino; new amino; synthesis new; iminopyrido pyrimidines ... See more keywords
Synthesis of new 1,3,4-oxadiazole and benzothiazolylthioether derivatives of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-one as potential antimycobacterial agents
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02420-7
Abstract: A new series of 4-[(substituted benzylidene)-3-[(5-(pyridine-4-yl)-1,3,4-oxadiazole-2-ylthio)-methyl]isoxazol-5(4H)-one (6a–g) and 4-(substituted benzylidene)-3-((benzo[d]thiazol-2-ylthio)methyl)isoxazol-5(4H)-one (8a–g) was synthesized. All the synthesized compounds were screened for antitubercular activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis BCG (ATCC 35743) and… read more here.
Keywords: new oxadiazole; synthesis new; isoxazol one; oxadiazole benzothiazolylthioether ... See more keywords
Synthesis of new 2-aminothiazolyl/benzothiazolyl-based 3,4-dihydropyrimidinones and evaluation of their effects on adenocarcinoma gastric cell migration.
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DOI: 10.1007/s11030-021-10229-z
Abstract: Gastric cancer is one of the malignant tumors of the gastrointestinal tract that, despite its decrease in recent years, is still the fourth most common cancer and the second leading cause of cancer-related death. Various… read more here.
Keywords: new aminothiazolyl; synthesis new; migration; cancer ... See more keywords
Simple and efficient synthesis of new tricarboxylic acids bearing cyclohexane and norbornane fragments
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DOI: 10.1007/s11172-017-1820-x
Abstract: A synthesis new aryl alicyclic tricarboxylic acids bearing two carboxyl groups at either cyclohexane or norbornane fragment and one carboxyl group at the benzene ring was devel-oped. Tricarboxylic acids of this type are promising monomers… read more here.
Keywords: synthesis new; acids bearing; tricarboxylic acids; cyclohexane norbornane ... See more keywords
Synthesis of new alkoxysilyl-substituted carboranes
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DOI: 10.1007/s11172-017-1826-4
Abstract: New 1,7-bis(trialkoxysilylpropyl)-m-carboranedicarboxamides were synthesized by the reaction of 3-aminopropyltrialkoxysilanes with either m-carboranedicarboxylic acid chloride in the presence of Et3N or m-carboranedicarboxylic acid in the presence of N,N´-carbonyl-diimidazole. The synthesized compounds are colorless liquids soluble in… read more here.
Keywords: alkoxysilyl substituted; synthesis new; new alkoxysilyl; synthesized compounds ... See more keywords
Synthesis of a new type of 1,3-diazaadamantan-6-ones
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DOI: 10.1007/s11172-017-1854-0
Abstract: A new type of 1,3-diazaadanamtan-6-ones was synthesized by heating the 3,7-di(tert-butyl)-1-[(tert-butylamino)methyl]bispidin-9-one derivatives with concentrated hydrobromic acid followed by condensation with formaldehyde. read more here.
Keywords: new type; synthesis new; type diazaadamantan; diazaadamantan ones ... See more keywords
Synthesis of new acridine-9-carboxylic acid derivatives
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DOI: 10.1007/s11172-018-2152-1
Abstract: New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesized compounds. read more here.
Keywords: synthesis new; acridine carboxylic; carboxylic acid; acid derivatives ... See more keywords