Chemoenzymatic Oxidation of Labdane and Formal Synthesis of Nimbolide.
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DOI: 10.1021/jacs.4c07956
Abstract: In nature, basic terpene skeletons are produced and subsequently undergo enzymatic or nonenzymatic oxidative transformations, leading to diverse structural variations. To date, thousands of natural products featuring a variety of oxidation patterns have been isolated… read more here.
Keywords: synthesis nimbolide; oxidation labdane; synthesis; formal synthesis ... See more keywords
Stereoselective Total Synthesis of Nimbolide.
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DOI: 10.1021/jacs.5c04899
Abstract: A stereoselective total synthesis of nimbolide has been achieved in a convergent, 11-step sequence from α-methyl-(R)-carvone. The strategy relied on a stereoselective palladium-catalyzed borylative Heck cyclization where the A-ring of the nimbolide core was constructed… read more here.
Keywords: total synthesis; stereoselective total; synthesis nimbolide;