Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800018
Abstract: Novel cycloalkene‐fused thienopyrimidine analogues with enhanced phosphodiesterase 5 (PDE5) inhibitory properties are presented. The structure of the reported scaffold was modulated through variation of the terminal cycloalkene ring size, as well as by varying the… read more here.
Keywords: design synthesis; synthesis novel; phosphodiesterase; phosphodiesterase pde5 ... See more keywords
Synthesis of novel cyanine dyes as antitumor agents
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000186
Abstract: In this study, some novel cyanine dyes, 1, 3, and 5−15, were synthesized by a one‐pot step reaction of pyridinium salts 2 and/or 4 with benzenaminium salt 1. N‐{[1‐Chloro‐3,4‐dihydronaphthalen‐2‐yl)methylene]benzenaminium} chloride 1 was obtained by the… read more here.
Keywords: synthesis novel; dyes antitumor; novel cyanine; cyanine dyes ... See more keywords
Synthesis of novel 2‐acetamide‐5‐phenylthio‐1,3,4‐thiadiazole‐containing phenyl urea derivatives as potential VEGFR‐2 inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100397
Abstract: A novel series of 2‐acetamide‐5‐phenylthio‐1,3,4‐thiadiazol derivatives containing a phenyl urea warhead were synthesized and evaluated as antiproliferative agents. The cytotoxic activities of the newly synthesized compounds were evaluated toward three human cancer cell lines, including… read more here.
Keywords: novel acetamide; synthesis novel; acetamide phenylthio; vegfr ... See more keywords
Facile Synthesis of Novel Amino Acids Derivatives as Potential Antibacterial Agents using Sustainable Materials
Sign Up to like & getrecommendations! Published in 2017 at "Journal of The Chinese Chemical Society"
DOI: 10.1002/jccs.201700054
Abstract: Following the principles of green chemistry, cardanol derivatives have been used as renewable, low-cost, and available natural starting materials to construct a variety of protected and unprotected amino acids derivatives. The reaction of cardanol derivatives… read more here.
Keywords: synthesis novel; amino acids; novel amino; facile synthesis ... See more keywords
Synthesis of novel heterocycles using 1,2,3‐triazole‐4‐carbohydrazides as precursors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.3840
Abstract: Herein, we report the synthesis of various heterocyclic ring systems containing 1,2,3‐triazole from the reactions of acid hydrazides and commercially available reagents, using efficient and simple procedures. Reactions of certain 1,2,3‐triazole‐4‐carbohydrazides and α‐bromoketones in boiling… read more here.
Keywords: synthesis novel; triazole carbohydrazides; heterocycles using; boiling ethanol ... See more keywords
Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines
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DOI: 10.1002/open.201800029
Abstract: Abstract Curcumin, a natural compound extracted from the rhizomes of Curcuma longa, displays pronounced anticancer properties but lacks good bioavailability and stability. In a previous study, we initiated structure modification of the curcumin scaffold by… read more here.
Keywords: synthesis novel; curcuminoids improved; novel aza; aza aromatic ... See more keywords
Synthesis of novel copper nanoparticles/ternary polymer blend nanocomposites and their structural, thermal and rheological properties and AC impedance
Sign Up to like & getrecommendations! Published in 2017 at "Polymer International"
DOI: 10.1002/pi.5373
Abstract: Face‐centred cubic (FCC) architecture for Cu unit, SEM morphology of dispersed Cu nanoparticles (NPs) and structure of Cu NPs/ternary blend nanocomposite. read more here.
Keywords: synthesis novel; nanoparticles ternary; ternary polymer; blend ... See more keywords
SELECTIVE SYNTHESIS OF A NOVEL GLYCOLURIL-BASED HYBRID COMPOUND WITH HIGH APPLICATION POTENTIAL
Sign Up to like & getrecommendations! Published in 2021 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/6179
Abstract: Highly selective synthesis of a new antipyrine-substituted tetracycle was implemented on the basis of a modified Mannich reaction as a result of the condensation of glycoluril with 4-aminoantipyrine in formalin without the use of catalysts. read more here.
Keywords: synthesis novel; selective synthesis; novel glycoluril; glycoluril based ... See more keywords
Microwave-assisted efficient and convenient one-pot synthesis of novel 3-(4-aminothieno[2,3-d]pyrimidin-5-yl)coumarins under solvent-free conditions
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-018-2340-9
Abstract: An efficient green synthesis of novel 3-(4-aminothieno[2,3-d]pyrimidin-5-yl)coumarins has been developed. One-pot reaction of 3-acetylcoumarin, malononitrile, and elemental sulfur, catalyzed by L-proline, resulted in the formation of thiophene derivatives, which were used as precursors for the… read more here.
Keywords: pyrimidin coumarins; synthesis novel; aminothieno pyrimidin; one pot ... See more keywords
Synthesis of novel 6-methyl-4-sulfanylfuro[3,4-с]pyridin-3(1H)-ones
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02584-5
Abstract: Alkylation of 6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one in an alkaline medium proceeds regioselectively at the sulfur atom to form sulfanyl derivatives. read more here.
Keywords: methyl sulfanylfuro; methyl; synthesis novel; sulfanylfuro pyridin ... See more keywords
Synthesis of a novel double-ligand nickel conductive metal–organic framework material and its electrochemical characterization for supercapacitors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Materials Science"
DOI: 10.1007/s10853-020-05378-9
Abstract: A new double-ligand Ni-MOF material was prepared using a one-step synthesis preparation and was evaluated as a supercapacitor electrode material. The synergistic effects provided by the double ligand and nickel significantly improved the material’s redox… read more here.
Keywords: synthesis novel; novel double; double ligand; ligand nickel ... See more keywords