Synthesis of Nucleoside and Nucleotide Analogues by Cyclization of the Guanine Base with 1,1,3,3-Tetramethoxypropane.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03252
Abstract: 3-(2-Deoxy-β-d-erythropentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one (M1dG) is an endogenous DNA adduct in bacterial and mammalian cells that could be explored as a biomarker for oxidative stress. Nonetheless, the lack of an efficient methodology for the preparation of M1dG hampers… read more here.
Keywords: analogues cyclization; guanine base; nucleoside nucleotide; nucleotide analogues ... See more keywords
Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2039620
Abstract: ABSTRACT Introduction Nucleoside analogues represent a cornerstone of achievement in drug discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery over the last 60 years. Traditionally accessed using chemical synthesis, a… read more here.
Keywords: drug discovery; nucleoside analogues; synthesis nucleoside; synthesis ... See more keywords
A short de novo synthesis of nucleoside analogs
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abb3231
Abstract: Short path to a complex ring Nucleotide analogs are valuable tools and therapeutics because of their ability to interfere with processes such as DNA synthesis, which are vital to rapidly dividing cells and replicating viruses.… read more here.
Keywords: novo synthesis; nucleoside analogs; reaction; short novo ... See more keywords
Unifying the synthesis of nucleoside analogs
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abd1283
Abstract: A short, versatile synthetic pathway transforms achiral reactants into nucleoside analogs Nucleosides, the building blocks of DNA and RNA, typically contain a ribose sugar attached to a nucleobase. Structurally modified nucleoside analogs can disrupt the… read more here.
Keywords: nucleoside analogs; unifying synthesis; virus; synthesis ... See more keywords