Scalable Synthesis of Orthogonally Protected β-Methyllanthionines by Indium(III)-Mediated Ring Opening of Aziridines.
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DOI: 10.1021/acs.orglett.9b00125
Abstract: Lantibiotics are a class of peptide antibiotics with activity against most Gram-positive bacteria. Lanthionine (Lan) and β-MeLan are unusual thioether-bridged, non-proteinogenic amino acids, which are characteristic features of lantibiotics. In this paper, we report the… read more here.
Keywords: ring opening; synthesis orthogonally; orthogonally protected; scalable synthesis ... See more keywords