Short Synthesis of Oxetane and Azetidine 3-Aryl-3-carboxylic Acid Derivatives by Selective Furan Oxidative Cleavage.
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DOI: 10.1021/acs.orglett.0c01214
Abstract: Four-membered rings remain underexplored motifs despite offering attractive physicochemical properties for medicinal chemistry. Arylacetic acids bearing oxetanes, azetidines, and cyclobutanes are prepared in two steps: a catalytic Friedel-Crafts reaction from four-membered ring alcohol substrates, followed… read more here.
Keywords: oxidative cleavage; synthesis oxetane; cleavage; short synthesis ... See more keywords
Solid-Phase Synthesis of Oxetane Modified Peptides.
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DOI: 10.1021/acs.orglett.7b01466
Abstract: Solid-phase peptide synthesis (SPPS) is used to create peptidomimetics in which one of the backbone amide C═O bonds is replaced by a four-membered oxetane ring. The oxetane containing dipeptide building blocks are made in three… read more here.
Keywords: phase synthesis; synthesis oxetane; solid phase; oxetane ... See more keywords