Biocatalytic Approaches for the Synthesis of Oxindoles
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DOI: 10.1002/cctc.202500591
Abstract: Oxindoles have demonstrated significant applications in medicinal chemistry and synthetic organic chemistry, making the development of efficient synthetic strategies for their preparation highly important. In addition to traditional chemical synthesis methods, biocatalysis has emerged as… read more here.
Keywords: chemistry; biocatalytic approaches; approaches synthesis; synthesis oxindoles ... See more keywords
A de novo Synthesis of Oxindoles from Cyclohexanone-Derived γ-Keto-ester Acceptors Using a Desaturative Amination–Cyclization Approach
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DOI: 10.1055/a-1538-8429
Abstract: Here we report a desaturative approach for oxindole synthesis. This method uses simple γ-ester-containing cyclohexanones and primary amine building blocks as coupling partners. A dual photoredox–cobalt manifold is used to generate a secondary aniline that,… read more here.
Keywords: synthesis oxindoles; novo synthesis; ester; approach ... See more keywords