Electrochemically promoted amination of pyrido[2,3‐d]pyrimidin‐7‐ones: efficient synthesis of palbociclib derivatives
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DOI: 10.1002/ejoc.202500259
Abstract: The pyrido[2,3‐d]‐pyrimidin‐7‐one template is a crucial molecular fragment in antineoplastic drug palbociclib. Considering the importance of pyrido[2,3‐d]‐pyrimidin‐7‐one template, herein, we report a simple and environmentally friendly electrocatalytic amination of pyrido[2,3‐d]pyrimidin‐7‐ones with N,N‐dialkyl formamides as the amine source and… read more here.
Keywords: pyrido pyrimidin; pyrimidin ones; synthesis palbociclib; amination pyrido ... See more keywords