Total Chemical Synthesis of Palmitoyl-Conjugated Insulin
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DOI: 10.1021/acsomega.2c07918
Abstract: Commercially available insulins are manufactured by recombinant methods for the treatment of diabetes. Long-acting insulin drugs (e.g., detemir and degludec) are obtained by fatty acid conjugation at LysB29 ε-amine of insulin via acid–amide coupling. There… read more here.
Keywords: insulin; synthesis palmitoyl; palmitoyl; chemical synthesis ... See more keywords