Enantioselective Total Synthesis of (+)-Pepluanol A.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00961
Abstract: Herein, we report an enantioselective and convergent total synthesis of (+)-pepluanol A, a structurally intriguing Euphorbia diterpenoid natural product featuring a 5/6/7/3-fused tetracyclic skeleton, from known building blocks in 11 steps. The successful strategy relies… read more here.
Keywords: pepluanol; reaction; synthesis pepluanol; enantioselective total ... See more keywords
Ten-Step Asymmetric Total Synthesis of (+)-Pepluanol A.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c05257
Abstract: The first asymmetric synthesis of pepluanol A (1) is presented. The synthesis route is very concise (10 steps) and features a Curtin-Hammett-driven stereoconvergent intramolecular Diels-Alder reaction. A Nozaki-Hiyama-Kishi reaction comprises the connective step, bringing together… read more here.
Keywords: reaction; synthesis pepluanol; synthesis; ten step ... See more keywords