Synthesis of phenylpyridine derivatives and their biological evaluation toward dipeptidyl peptidase-4
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DOI: 10.1007/s10593-017-2062-4
Abstract: A novel series of pyridine-based derivatives was synthesized and evaluated for their inhibitory activity against dipeptidyl peptidase-4 (DPP4). 5-Aminomethyl-6-(2,4-dichlorophenyl)-4-[(1H-1,2,4-triazol-1-yl)methyl]pyridine-2-carboxylic acid was identified as a potent (IC50 0.57 nM) and selective DPP4 inhibitor (DPP8/DPP4 = 238).… read more here.
Keywords: phenylpyridine derivatives; biological evaluation; peptidase; synthesis phenylpyridine ... See more keywords