Synthesis of polyfunctionalized 1,1'-(α,ω-alkanediyl)bis(1,2,3,4-tetrahydropyridines)
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-017-2176-8
Abstract: A one-pot reaction was developed for the synthesis of polyfunctionalized 1,1'-(α,ω-alkanediyl)bis(1,2,3,4-tetrahydropyridines) in 28–69% yields on the basis of a three-component reaction between 1,3-dicarbonyl compounds, aqueous 33% solution of formaldehyde, and α,ω-diamines. read more here.
Keywords: polyfunctionalized alkanediyl; alkanediyl bis; bis tetrahydropyridines; synthesis polyfunctionalized ... See more keywords
An efficient and green synthesis of polyfunctionalized spirothiazolidin-4-ones using sulfonated mesoporous silica as a reusable catalyst
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DOI: 10.1007/s10593-017-2185-7
Abstract: A simple and highly efficient protocol was developed for one-pot synthesis of polyfunctionalized spirothiazolidin-4-ones using sulfonated mesoporous silica (MCM-SO3H) as a heterogenous and reusable acidic catalyst. In comparison to the reported synthetic methods for the… read more here.
Keywords: spirothiazolidin ones; synthesis polyfunctionalized; polyfunctionalized spirothiazolidin; ones using ... See more keywords
Fast MacMillan’s Imidazolidinone-Catalyzed Enantioselective Synthesis of Polyfunctionalized 4-Isoxazoline Scaffolds
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DOI: 10.1021/acsomega.2c03477
Abstract: The enantioselective 1,3-dipolar cycloaddition of nitrones and arylpropionaldehydes to generate highly functionalized scaffolds for application in drug discovery was herein investigated. The use of a second-generation MacMillan catalyst as hydrochloride salt consistently accelerated the reaction… read more here.
Keywords: enantioselective synthesis; imidazolidinone catalyzed; macmillan imidazolidinone; synthesis polyfunctionalized ... See more keywords
Substrate-directed chemo- and regioselective synthesis of polyfunctionalized trifluoromethylarenes via organocatalytic benzannulation
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/c9qo01436e
Abstract: Highly chemo- and regioselective substrate-directed benzannulation of trisubstituted CF3-alkenes and 2-benzylidenemalononitriles or 2-nitroallylic acetates has been achieved via Michael-initiated [4 + 2] or Rauhut–Currier-initiated [3 + 3] annulation. These protocols enable the rapid assembly of… read more here.
Keywords: synthesis polyfunctionalized; chemo regioselective; substrate directed; directed chemo ... See more keywords
A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24244575
Abstract: Highly functionalized furans are the key scaffolds of many pharmaceuticals and bioactive natural products. Herein, we disclose a new fruitful synthesis of polyfunctionalized furans starting from β-nitroenones and α-functionalized ketones. The protocol involves two steps… read more here.
Keywords: starting nitroenones; synthesis polyfunctionalized; new valuable; furans starting ... See more keywords