Synthesis and potent antimicrobial activity of novel coumarylthiazole α-aminophosphonates derivatives.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10242-2
Abstract: Herein, we reported a novel series of α-aminophosphonates derivatives (IV)a-m bearing an important pharmacophore coumarylthiazole moiety. All the new compounds have been synthesized via Kabachnik-Fields reaction under ultrasonic irradiation. The products were obtained in good yield with a… read more here.
Keywords: aminophosphonates derivatives; antimicrobial activity; synthesis potent; potent antimicrobial ... See more keywords
Hypoglycemic and hypolipidemic dual activities of extracts and flavonoids from Desmodium caudatum and an efficient synthesis of the most potent 8-prenylquercetin.
Sign Up to like & getrecommendations! Published in 2021 at "Fitoterapia"
DOI: 10.1016/j.fitote.2021.105083
Abstract: Since glucolipid metabolism disorders is often the mono-target therapy fails in managing blood glucose and lipid levels and the other complications, it is urgent and necessary to seek for the new potential drugs or functional… read more here.
Keywords: prenylquercetin; dual activities; efficient synthesis; synthesis potent ... See more keywords
Synthesis of potent neuroprotective butenolides based on plant smoke derived 3,4,5-Trimethylfuran-2(5H)-one and 3-methyl-2H-furo[2,3-c]pyrone-2-one.
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2019.03.014
Abstract: Smoke derived karrikinolide and trimethylbutenolide exerted neuroprotective effects against monoamine oxidase and acetylcholinesterase. Synthesis of potent analogs was achieved. Sulphur substitution in the bicyclic ring structure of KAR1 displayed the most encouraging activity returning IC50… read more here.
Keywords: neuroprotective butenolides; smoke derived; potent neuroprotective; synthesis potent ... See more keywords
An efficient and scalable synthesis of potent TLR2 agonistic PAM2CSK4
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DOI: 10.1039/c8ra01387j
Abstract: Diacylated PAM2CSK4, a highly expensive lipopeptide with desirable aqueous solubility and a broad spectrum of cytokine/chemokine induction is a most potent dual (human and murine) Toll-Like Receptor-2 (TLR2) agonist. Besides such thrilling characteristics, its synthetic… read more here.
Keywords: synthesis potent; efficient scalable; scalable synthesis; synthesis ... See more keywords
Synthesis of potent and selective HDAC6 inhibitors led to unexpected opening of a quinazoline ring
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra01753a
Abstract: Histone deacetylase (HDAC) inhibitors are highly involved in the regulation of many pharmacological responses, which results in anti-inflammatory and anti-cancer effects. In the present work, chemoinformatic analyses were performed to obtain two potent and selective… read more here.
Keywords: hdac6 inhibitors; inhibitors led; selective hdac6; synthesis potent ... See more keywords
Improved Synthesis of Yt-14, A Potent Antibiotic to Multidrug-Resistant Strains
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Chemical Research"
DOI: 10.3184/174751918x15314830456124
Abstract: A new practical synthetic approach produced clinical drug candidate YT-14, improving the overall yield from 1.3% to 13.8%. Compared with the previous route, the new route is two steps shorter and all of the steps… read more here.
Keywords: improved synthesis; potent antibiotic; antibiotic multidrug; synthesis potent ... See more keywords