Design, Synthesis, and Preclinical Activity in Ovarian Cancer Models of New Phosphanegold(I)-N-heterocyclic Carbene Complexes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00737
Abstract: A new series of seven gold(I) complexes (1-7) containing 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (IPr) and phosphane ligands (L1-L7) were synthesized and evaluated for antitumor activity in ovarian cancer (OvCa) models. The synthesized complexes were characterized by IR, mass… read more here.
Keywords: design synthesis; ovarian cancer; activity; activity ovarian ... See more keywords
Synthesis and preclinical characterization of novel ruthenium (II) arene complexes for the treatment of solid tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e14512
Abstract: e14512Background: The development of metallopharmaceutics has placed organometallic ruthenium (II) complexes in the spotlight of interest. Although platinum agents are still the main therapeutic op... read more here.
Keywords: ruthenium; characterization novel; synthesis preclinical; preclinical characterization ... See more keywords
Synthesis and Preclinical Evaluation of Small-Molecule Prostate-Specific Membrane Antigen-Targeted Abiraterone Conjugate
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27248795
Abstract: Prostate cancer is the second most common type of cancer among men. The main method of its treatment is androgen deprivation therapy, which has a wide range of side effects. One of the solutions to… read more here.
Keywords: small molecule; prostate; abiraterone conjugate; synthesis preclinical ... See more keywords