Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111563
Abstract: Matrix metalloproteinases (MMPs) play important roles in many diseases including cancer. With moderate metal-binding affinity, 8-hydroxyquinoline has gained much interest in current drug design and development. Specially, it has been reported that 8-hydroxyquinoline derivatives serve… read more here.
Keywords: mmp; mmp mmp; design synthesis; synthesis preliminary ... See more keywords
Synthesis and preliminary anticancer evaluation of new triazole bisphosphonate-based isoprenoid biosynthesis inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113241
Abstract: The synthesis of a new set of triazole bisphosphonates 8a-d and 9a-d presenting an alkyl or phenyl substituent at the C-4 or C-5 position of the triazole ring is described. These compounds have been evaluated… read more here.
Keywords: anticancer evaluation; new triazole; biosynthesis; evaluation new ... See more keywords
Synthesis and preliminary study of pure and Zr-doped YMnO3 compounds as Solid Oxide Fuel Cells electrode
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Alloys and Compounds"
DOI: 10.1016/j.jallcom.2016.08.125
Abstract: Abstract The Y1−xZrxMnO3 series (0 ≤ x ≤ 0.30) has been studied to be used as possible SOFC electrode material. These compounds adopt a layered structure of hexagonal symmetry in which the manganese cations are located in trigonal bi-pyramidal… read more here.
Keywords: doped ymno3; synthesis preliminary; preliminary study; pure doped ... See more keywords
Design, Synthesis, And Preliminary Bioactivity Evaluation Of 2,7-Substituted Carbazole Derivatives As Potent Autotaxin Inhibitors And Antitumor Agents.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520618666180830161821
Abstract: BACKGROUND Autotaxin-LPA signaling has been implicated in cancer progression, and targeted for the discovery of cancer therapeutic agents. OBJECTIVE Potential ATX inhibitors were synthesized to develop novel leading compounds and effective anticancer agents. METHOD The… read more here.
Keywords: design synthesis; bioactivity evaluation; preliminary bioactivity; synthesis preliminary ... See more keywords
Synthesis And Preliminary Antimicrobial Evaluation Of Schiff Bases Of N -Benzyl Isatin Derivatives -
Sign Up to like & getrecommendations! Published in 2020 at "Systematic Reviews in Pharmacy"
DOI: 10.31838/srp.2020.12.297
Abstract: Isatin (1H-indole-2,3-dione) and its analogs are an important class of heterocyclic compounds. N-benzyl isatins and Schiff bases of isatin analogs have been reported to demonstrate a variety of biological activities. This work illustrates the synthesis… read more here.
Keywords: schiff; synthesis preliminary; activity; antimicrobial evaluation ... See more keywords
Synthesis and Preliminary Evaluation of the Cytotoxicity of Potential Metabolites of Quinoline Glycoconjugates
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27031040
Abstract: The design of prodrugs is one of the important strategies for selective anti-cancer therapies. When designing prodrugs, attention is paid to the possibility of their targeting tumor-specific markers such as proteins responsible for glucose uptake.… read more here.
Keywords: cytotoxicity potential; cytotoxicity; preliminary evaluation; potential metabolites ... See more keywords
Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15051467
Abstract: The search for disease-modifying agents targeted against Parkinson’s disease led us to rationally design a small array of six Anle138b-centered PROTACs, 7a,b, 8a,b and 9a,b, targeting αSynuclein (αSyn) aggregates for binding, polyubiquitination by the E3… read more here.
Keywords: aggregation; anle138b centered; centered protacs; syn aggregation ... See more keywords
Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain
Sign Up to like & getrecommendations! Published in 2023 at "Materiale Plastice"
DOI: 10.37358/mp.23.1.5639
Abstract: Bromelain, a natural substance sourced from pineapples, was found effective in various colds, in preventing heart attack and respectively in excess weight. On the other hand, it is well-known that pineapples juice increases the gastric… read more here.
Keywords: bromelain; preliminary characterization; polyurethane matrices; drug ... See more keywords