Synthesis of Pyranones: Ru-Catalyzed Cascade Reaction via Vinylic C-H Addition to Glyoxylate.
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DOI: 10.1021/acs.orglett.2c01614
Abstract: The efficient synthesis of pyranones is presented by a three-component cascade reaction from readily available acrylic acids, ethyl glyoxylate, and p-toluenesulfonamide under ruthenium catalysis. For the first time, the nucleophilic addition of the vinylic C-H… read more here.
Keywords: addition; catalyzed cascade; synthesis pyranones; pyranones catalyzed ... See more keywords
Base-Promoted Selective Synthesis of 2H-Pyranones and Tetrahydronaphthalenes via Domino Reactions
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DOI: 10.1021/acsomega.7b00627
Abstract: A highly efficient domino protocol has been developed for the synthesis of 6-aryl-4-(methylthio/amine-1-yl)-2-oxo-2H-pyran-3-carbonitriles and 4-aryl-2-(amine-1-yl)-5,6,7,8-tetrahydronaphthalene-1-carbonitriles from simple and readily available α-aroylketene dithioacetals, malononitrile, secondary amines, and cyclohexanone. This elegant domino process involved consecutive addition–elimination, intramolecular… read more here.
Keywords: selective synthesis; domino; promoted selective; synthesis pyranones ... See more keywords