K 3 PO 4 promoted dipolar [3+3] cyclization: Direct synthesis of pyrazino[2,1- a ]isoquinoline derivatives
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DOI: 10.1016/j.tetlet.2017.12.011
Abstract: Abstract A K 3 PO 4 promoted dipolar [3+3] cyclization of dihydroisoquinoline imines and arylacyl bromides has been developed. This process realized the direct synthesis of pyrazino[2,1- a ]isoquinoline derivatives in 44–69% yields. A head… read more here.
Keywords: dipolar cyclization; direct synthesis; synthesis pyrazino; isoquinoline derivatives ... See more keywords
Regiodivergent synthesis of pyrazino-indolines vs. triazocines via α-imino carbenes addition to imidazolidines†‡
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc05725h
Abstract: Hexahydropyrazinoindoles were prepared in a single step from N-sulfonyl triazoles and imidazolidines. Under dirhodium catalysis, α-imino carbenes were generated and formed nitrogen ylide intermediates that, after subsequent aminal opening, afforded the pyrazinoindoles predominantly via formal… read more here.
Keywords: pyrazino indolines; regiodivergent synthesis; imino; synthesis pyrazino ... See more keywords