Lipase mediated multicomponent synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione derivatives in binary solvent medium.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2264
Abstract: A new method for the synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via lipase from Aspergillus niger (ANL) catalyzed multicomponent reaction of aldehydes, malononitrile, and phthalhydrazide is reported herein for the first time. This novel method holds several… read more here.
Keywords: phthalazine dione; synthesis pyrazolo; lipase; dione derivatives ... See more keywords
β-Cyclodextrin as a Supramolecular Catalyst for the Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione Derivatives in Water
Sign Up to like & getrecommendations! Published in 2017 at "Catalysis Letters"
DOI: 10.1007/s10562-017-2032-6
Abstract: An efficient and green method has been developed for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives by employing 20 mol% β-cyclodextrin via a one-pot multicomponent reaction of aldehydes, malononitrile and phthalhydrazide in H2O–EtOH (4:1) at 100 °C for first… read more here.
Keywords: pyrazolo phthalazine; catalyst; synthesis pyrazolo;
Synthesis of pyrazolo- and [1,2,4]triazolo-[1,5-а]quinolin-9-ols by cycloaddition to 8-hydroxyquinoline N-imide
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DOI: 10.1007/s10593-019-02446-0
Abstract: The reaction of 1-amino-8-hydroxyquinolinium mesitylenesulfonate with alkenes and alkynes containing electron-withdrawing substituents was performed in MeCN–K2СО3 system and gave the respective 9-hydroxypyrazolo[1,5-a]quinolines. The reaction with acetonitrile\ and aromatic nitriles in aqueous 2 N KОН solution… read more here.
Keywords: quinolin ols; triazolo; ols cycloaddition; triazolo quinolin ... See more keywords
Synthesis of pyrazolo[1,5-a]pyrazin-4-ylacetonitriles and their annulation with pyridine ring
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DOI: 10.1007/s10593-019-02554-x
Abstract: A reaction of 4-chloropyrazolo[1,5-a]pyrazines with tert-butyl cyanoacetate proceeded via the formation of tert-butyl cyano(pyrazolo- [1,5-a]pyrazin-4(5H)-ylidene)ethanoates as intermediates and led to pyrazolo[1,5-a]pyrazin-4-ylacetonitriles, which were used to obtain derivatives of a new pyrazolo[1,5-a]pyrido[2,1-c]pyrazine system. read more here.
Keywords: ylacetonitriles annulation; pyrazin ylacetonitriles; pyrazolo pyrazin; synthesis pyrazolo ... See more keywords
Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.06.055
Abstract: A series of hybrid aza heterocycles containing pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazole scaffold were synthesized from 1,3-dipolar cycloaddition reaction of pyrazolopyrimidinone based alkyne with azides using Cu(II) catalyst in presence of sodium ascorbate and evaluated for… read more here.
Keywords: ones tethered; pyrazolo pyrimidin; pyrimidin ones; synthesis pyrazolo ... See more keywords
Experimental and DFT mechanistic insights into one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones under catalysis of DBU-based ionic liquids
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DOI: 10.1039/d0nj03478a
Abstract: Benzylation of DBU followed by anion exchange of the resulting salt with trifluoroacetate gave nearly quantitatively the ionic liquid [Bn-DBU][TFA]. It is shown here to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones via… read more here.
Keywords: ionic liquid; phthalazine diones; synthesis pyrazolo; dbu ... See more keywords