Design and Synthesis of Pyrrolidine-based Fragments That Sample Three-dimensional Molecular Space.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00070
Abstract: Fragment-based drug discovery (FBDD) is a well-established technology for lead compound generation in drug discovery. As this technology has evolved, the design of fragments for screening has also evolved to engender not just an understanding… read more here.
Keywords: pyrrolidine based; design synthesis; based fragments; synthesis pyrrolidine ... See more keywords
Synthesis of pyrrolidine-based hamamelitannin analogues as quorum sensing inhibitors in Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2018 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.14.260
Abstract: Interfering with bacterial cell-to-cell communication is a promising strategy to combat antimicrobial resistance. The natural product hamamelitannin and several of its analogues have been identified as quorum sensing inhibitors. In this paper the synthesis of… read more here.
Keywords: synthesis pyrrolidine; pyrrolidine based; hamamelitannin; quorum sensing ... See more keywords