Mechanistic Studies on the Synthesis of Pyrrolidines and Piperidines via Copper-Catalyzed Intramolecular C–H Amination
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DOI: 10.1021/acs.organomet.2c00095
Abstract: We have recently developed a method for the synthesis of pyrrolidines and piperidines via intramolecular C–H amination of N-fluoride amides using [TpxCuL] complexes as precatalysts [Tpx = tris(pyrazolyl)borate ligand and L = THF or CH3CN].… read more here.
Keywords: copper; pyrrolidines piperidines; mechanistic studies; piperidines via ... See more keywords
Asymmetric Synthesis of Pyrrolidines via Oxetane Desymmetrization.
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DOI: 10.1021/acs.orglett.2c00564
Abstract: Asymmetric synthesis of chiral pyrrolidines bearing an all-carbon quaternary stereocenter in the 3-position remains challenging. Herein we report two efficient protocols by means of oxetane desymmetrization, featuring the use of a readily available tert-butylsulfinamide chiral… read more here.
Keywords: pyrrolidines via; oxetane desymmetrization; asymmetric synthesis; synthesis pyrrolidines ... See more keywords
Enantioselective Synthesis of Pyrrolidines by a Phosphine-Catalyzed γ-Umpolung/β-Umpolung Cascade.
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DOI: 10.1021/acs.orglett.2c00785
Abstract: Herein, we report an enantioselective catalytic annulation of electron-poor allenes with aminocrotonates. The reaction proceeds by the umpolung γ-amination of the allenoate and β-umpolung intramolecular conjugate addition. The reaction provides ready access to pyrrolidines using… read more here.
Keywords: umpolung umpolung; enantioselective synthesis; synthesis pyrrolidines; pyrrolidines phosphine ... See more keywords