Base-catalyzed synthesis of quinazolines in aqueous medium
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151186
Abstract: Abstract An alternative green protocol and step economy for the synthesis of quinazoline has been developed. The reaction of readily available 2-aminobenzonitriles with various organometallic reagents led to ortho-aminoaryl N H ketimine species. The subsequent… read more here.
Keywords: aqueous medium; base catalyzed; synthesis quinazolines; catalyzed synthesis ... See more keywords
Copper-catalyzed synthesis of quinazolines via cascade cyclization/hydrodehalogenation
Sign Up to like & getrecommendations! Published in 2023 at "New Journal of Chemistry"
DOI: 10.1039/d3nj00541k
Abstract: We report a Cu(i)-catalyzed synthesis of quinazolines via cascade cyclization/hydrodehalogenation by using acetamide as a nitrogen source and H2O as a hydrogen source. read more here.
Keywords: cascade cyclization; cyclization hydrodehalogenation; quinazolines via; via cascade ... See more keywords
Transition-metal-catalyzed synthesis of quinazolines: A review
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1140562
Abstract: Quinazolines are a class of nitrogen-containing heterocyclic compounds with broad-spectrum of pharmacological activities. Transition-metal-catalyzed reactions have emerged as reliable and indispensable tools for the synthesis of pharmaceuticals. These reactions provide new entries into pharmaceutical ingredients… read more here.
Keywords: transition metal; synthesis quinazolines; metal catalyzed;
Recent Advances in the Transition-Metal-Free Synthesis of Quinazolines
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28073227
Abstract: Quinazolines are a privileged class of nitrogen-containing heterocycles, widely present in a variety of natural products and synthetic chemicals with a broad spectrum of biological and medicinal activities. Owing to their pharmaceutical applications and promising… read more here.
Keywords: metal free; transition metal; synthesis quinazolines; free synthesis ... See more keywords