Total Synthesis of Resiniferatoxin Enabled by Photocatalytic Decarboxylative Radical Cyclization.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04286
Abstract: Resiniferatoxin (1) is a complex daphnane diterpenoid with a highly oxygenated 5/7/6-membered ABC-ring system. Here we report a new synthetic route to 1 that requires 27 steps from a starting d-ribose derivative. The carbon spacer… read more here.
Keywords: resiniferatoxin; synthesis resiniferatoxin; resiniferatoxin enabled; decarboxylative radical ... See more keywords
Total Synthesis of Resiniferatoxin.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08200
Abstract: From both structural and functional perspectives, the large family of daphnane diterpene orthoesters (DDOs) represent a truly remarkable class of natural products. As potent lead compounds for the treatment of pain, neurodegeneration, HIV/AIDS, and cancer,… read more here.
Keywords: total synthesis; synthesis resiniferatoxin; synthesis;
Total Synthesis of Resiniferatoxin Enabled by Radical-Mediated Three-Component Coupling and 7-endo Cyclization.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b10177
Abstract: Resiniferatoxin (1) belongs to a daphnane diterpenoid family and has strong agonistic effects on TRPV1, a transducer of noxious temperature and chemical stimuli. The densely oxygenated trans-fused 5/7/6-tricarbocycle (ABC-ring) of 1 presents a daunting challenge… read more here.
Keywords: endo cyclization; synthesis resiniferatoxin; synthesis; total synthesis ... See more keywords