Synthesis of A-B-C-ring Tricyclic Core of iso-Merrilactone A
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-019-9064-y
Abstract: A desymmetrization approach for the synthesis of the A-B-C tricycle intermediate of iso-merrilactone A was described. The key steps of this synthesis to efficiently access the tetracyclic Illicium sesquiterpenes core included an intramolecular aldol cyclization… read more here.
Keywords: iso merrilactone; synthesis ring; synthesis; core ... See more keywords
Synthesis of Ring-Locked Tetracyclic Dithienocyclopentapyrans and Dibenzocyclopentapyran via 1,5-Hydride Shift and Copper-Catalyzed C-O Bond Formation for Nonfullerene Acceptors.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00110
Abstract: We discovered a unique synthetic route to construct 2H-pyran-containing tetracyclic dithienocyclopentapyran (DTCP) and dibenzocyclopentapyran (DBCP) architectures. The synthesis involves an acid-induced dehydration cyclization followed by a [1,5] hydride-shift isomerization to form a cyclopentanone moiety which… read more here.
Keywords: synthesis ring; hydride shift; bond formation;
Synthesis of Ring-Opened Analogues of Oxysterol-Binding Protein-Inhibiting Piperidinyl-thiazole Fungicides
Sign Up to like & getrecommendations! Published in 2017 at "Synlett"
DOI: 10.1055/s-0036-1588473
Abstract: Novel aminoethyl-, aminopropyl-, and aminobutyl-substituted thiazole-4-carboxamides have been prepared which are ring-opened analogues of piperidinyl-thiazole fungicides. Depending of the chain length, completely different synthetic approaches had to be chosen which vary from a Sonogashira coupling… read more here.
Keywords: thiazole fungicides; ring opened; synthesis ring; piperidinyl thiazole ... See more keywords
Selective synthesis of A-ring Е-arylidene derivatives from β-sitosterol and their activity.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2103555
Abstract: A series of 24-ethylcholest-4-ene-3,6-dione 2E-arylidene-derivatives has been synthesized by a Claisen-Schmidt reaction from a natural phytosterol β-sitosterol with yields of 80-85%. The structure of the obtained compounds was confirmed by NMR spectroscopy, including two-dimensional correlation… read more here.
Keywords: arylidene derivatives; ring arylidene; selective synthesis; derivatives sitosterol ... See more keywords
Synthesis of ring-A modified lupeol derivatives and their anti-proliferative activity: identification of potent lead active against MCF-7 breast cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2121827
Abstract: In continuation of our research program aimed at the development of new natural product-based anticancer agents, a series of lupeol derivatives (5a-5k and 6a-6i) were prepared with the introduction of aryl functionalities and amino acids… read more here.
Keywords: lupeol derivatives; activity; synthesis ring; mcf7 cells ... See more keywords
Design and synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives via click reactions
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Research"
DOI: 10.1177/1747519820919853
Abstract: The synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives at the 4-OH via click reactions is accomplished, and a total of 16 novel sinomenine double N-heterocyclic derivatives are obtained in 74%–95% yields. The C-ring is first… read more here.
Keywords: substituted sinomenine; ring quinoxaline; synthesis ring; quinoxaline substituted ... See more keywords
Improved Synthesis of the A–E Ring Segment of Ciguatoxin CTX3C by Using Intramolecular Allylations
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1246/bcsj.20170390
Abstract: An improved synthesis of the A–E ring segment of ciguatoxin CTX3C is described. The E ring segment was synthesized by the intramolecular reaction of allylic stannane and aldehyde with high stereoselectivity. Construction of the A–E… read more here.
Keywords: improved synthesis; ring segment; segment; synthesis ring ... See more keywords