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Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300185
Abstract: A series of 16 novel spirooxindole analogs 8a-p were designed and constructed via cost-effective single-step multicomponent [3+2] cycloaddition reaction of azomethine ylide (AY) generated in situ from substituted isatin (6a-d) with suitable amino acids (7a-c)…
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Keywords:
mcf;
novel spiro;
synthesis sars;
sars study ... See more keywords
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Published in 2022 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20220033
Abstract: The 3-chymotrypsin-like protease (3CLpro) is an attractive target for the development of anti- SARS (severe acute respiratory syndrome) drugs. In this work, a series of oxazolidinone derivatives 3a-3v were synthesized and their inhibitory activities against…
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Keywords:
protease inhibitory;
sars cov;
synthesis sars;
3cl protease ... See more keywords