Design, Synthesis, and Screening of Triazolopyrimidine–Pyrazole Hybrids as Potent Apoptotic Inducers
Sign Up to like & getrecommendations! Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201700137
Abstract: An efficient synthesis of novel 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐5,7‐dimethyl‐[1,2,4]triazolo[4,3‐a]‐pyrimidines was accomplished by the oxidation of pyrimidinylhydrazones by using organoiodine(III) reagent. All new triazolopyrimidine derivatives bearing the pyrazole scaffold were screened to evaluate them as a reproductive toxicant in… read more here.
Keywords: design synthesis; screening triazolopyrimidine; testicular germ; germ cells ... See more keywords
Synthesis, screening and biological activity of potent thiosemicarbazone compounds as a tyrosinase inhibitor
Sign Up to like & getrecommendations! Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c9nj02360g
Abstract: Inhibitors are designed based on coordination chemistry and catalytic circle of the tyrosinase, coordination atoms binds to copper and blocks enzyme activity, indicated that thiosemicarbazone species possess good potential as tyrosinase inhibitors. read more here.
Keywords: thiosemicarbazone; biological activity; activity; screening biological ... See more keywords
Abstract B66: High-throughput synthesis and screening for tumor-targeting liposomal nanoparticles
Sign Up to like & getrecommendations! Published in 2020 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm18-b66
Abstract: The identification of therapeutic nanoparticles formulation with preferential distribution to the tumor microenvironment remains an unsolved challenge. We have developed a high-throughput synthesis and screening platform to discover novel tumor-targeting liposomal nanoparticles. Over 1,000 unique… read more here.
Keywords: immunology; throughput synthesis; tumor; synthesis screening ... See more keywords
Synthesis and screening of anticancer potentials of some new terephthaldehyde-derived nitrone compounds
Sign Up to like & getrecommendations! Published in 2020 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v19i2.17
Abstract: Purpose: To synthesize and screen some new nitrone compounds derived from terephthaldehyde for their anticancer potential. Methods: Six new compounds (H, p-Me,p-Br, p-Cl, o-Cl and m-Me) were synthesized via a condensation reaction between terephthaldehyde and… read more here.
Keywords: mcf cells; screening anticancer; nitrone compounds; synthesis screening ... See more keywords