Mechanistic Insight into the Catalytic Promiscuity of Amine Dehydrogenases: Asymmetric Synthesis of Secondary and Primary Amines
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DOI: 10.1002/cbic.201800626
Abstract: Biocatalytic asymmetric amination of ketones, by using amine dehydrogenases (AmDHs) or transaminases, is an efficient method for the synthesis of α‐chiral primary amines. A major challenge is to extend amination to the synthesis of secondary… read more here.
Keywords: primary amines; synthesis secondary; nad dependent; secondary amines ... See more keywords
Synthesis of Secondary Amines via Self-Limiting Alkylation
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DOI: 10.1021/acs.orglett.4c01430
Abstract: N-centered nucleophilicity increases upon alkylation, and thus selective partial alkylation of ammonia and primary amines can be challenging: Poor selectivity and overalkylation are often observed. Here we introduce N-aminopyridinium salts as ammonia surrogates for the… read more here.
Keywords: chemistry; via self; secondary amines; alkylation ... See more keywords
Enantioselective Synthesis of Secondary β-Trifluoromethyl Alcohols via Catalytic Asymmetric Reductive Trifluoroalkylation and Diastereoselective Reduction.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c01422
Abstract: Fluorinated motifs are frequently encountered in drugs and agrochemicals. Incorporating fluorine-containing motifs in drug candidates for lead optimization in pharmaceutical research and development has emerged as a powerful tool. The construction of molecules that feature… read more here.
Keywords: trifluoroalkylation; enantioselective synthesis; synthesis secondary; reduction ... See more keywords