Enzymatic synthesis of sitagliptin intermediate using a novel ω-transaminase.
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DOI: 10.1016/j.enzmictec.2018.10.003
Abstract: Enantiopure β-amino acids are essential precursors of various pharmaceuticals, agrochemicals and other industrially important chemicals. In this study, we selected sixteen potential ω-Transaminases (ω-TAs) by BLAST and phylogenetic tree analysis. These ω-TAs were cloned, purified… read more here.
Keywords: amino; enzymatic synthesis; sitagliptin intermediate; synthesis ... See more keywords