Synthesis of spirooxindole analogues from 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde
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DOI: 10.1080/00397911.2019.1704009
Abstract: Abstract A series of spirooxindoles have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide generated from isatin and sarcosine or L-proline with the dipolarophile (E)-3-(2-cyclopropyl-5-(4-fluorophenyl) quinolin-3-yl)-1-phenylprop-2-en-1-one derivatives. The stereochemistry of the cycloadducts was assigned… read more here.
Keywords: fluorophenyl quinoline; cyclopropyl fluorophenyl; analogues cyclopropyl; synthesis spirooxindole ... See more keywords
Ammonium acetate mediated simple, rapid, and one-pot multicomponent synthesis of spirooxindole derivatives
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DOI: 10.1080/00397911.2023.2199357
Abstract: Abstract Synthesis of spirooxindole derivatives was achieved by combining Knoevenagel condensation and Michael addition between isatin, malononitrile, and dimedone or cyclohexan-1,3-dione in presence of ammonium acetate by simple stirring in ethanol at room temperature. Spirooxindole… read more here.
Keywords: acetate mediated; synthesis spirooxindole; mediated simple; ammonium acetate ... See more keywords