Direct N-H/α,α,β,β-C(sp3)-H functionalization of piperidine via an azomethine ylide route: synthesis of spirooxindoles bearing 3-substituted oxindoles.
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DOI: 10.1039/c6cc08996h
Abstract: A protocol for the direct functionalization of N-H/α,α,β,β-C(sp3)-H of piperidine without any metal or external oxidants is reported. This reaction is promoted by 4-(trifluoromethyl)benzoic acid via an azomethine ylide intermediate. This is a simple method… read more here.
Keywords: via azomethine; bearing substituted; synthesis spirooxindoles; azomethine ylide ... See more keywords