Synthesis and stereochemistry assignment of (3R,5R)- and (3S,5R)-4-benzyl-3-(3,4-dimethoxyphenyl)-5-phenyl-1,4-oxazin-2-ones
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DOI: 10.1016/j.molstruc.2019.05.091
Abstract: Abstract The diastereoselective synthesis of 3,5-disubstituted 1,4-oxazin-2-ones, the valuable intermediates on the route to tetrahydroisoquinoline derivatives, was based on the Petasis reaction in which (R)-(−)-N-benzyl-2-phenylglycinol was used as the amine component. It was demonstrated that… read more here.
Keywords: synthesis stereochemistry; oxazin ones; benzyl; stereochemistry assignment ... See more keywords
Synthesis and stereochemistry of decarestrictines H and J
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DOI: 10.1016/j.tet.2017.02.023
Abstract: Abstract The first synthesis of (7S,9R)-decarestrictine H and (7R,9R)-decarestrictine H as well as the improved synthesis of decarestrictine J were achieved. The overall yields of (7S,9R)-decarestrictines H and J were 20.9% each in nine to… read more here.
Keywords: decarestrictine; stereochemistry decarestrictines; synthesis; synthesis stereochemistry ... See more keywords
Synthesis and stereochemistry of JBIR-81, a peptide enamide derived from aspergilli
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DOI: 10.1016/j.tetlet.2018.01.080
Abstract: Abstract The absolute stereochemistry of an aspergilli-derived peptide enamide, JBIR-81, was determined to be 12S, 15S by the first synthesis of (12S,15S)-JBIR-81 and its epimer. The overall yield was 56% over six steps from N-methyl-… read more here.
Keywords: jbir peptide; synthesis stereochemistry; peptide enamide; stereochemistry jbir ... See more keywords