Design and Synthesis of 5‐Substituted Benzo[d][1,3]dioxole Derivatives as Potent Anticonvulsant Agents
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DOI: 10.1002/ardp.201600274
Abstract: A series of 5‐substituted benzo[d][1,3]dioxole derivatives was designed, synthesized, and tested for anticonvulsant activity using the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens. Neurotoxicity was determined by rotarod test. In the preliminary screening, six… read more here.
Keywords: design synthesis; derivatives potent; synthesis substituted; dioxole derivatives ... See more keywords
Synthesis of substituted 2H‐chromenes catalyzed by lipase immobilized on magnetic multiwalled carbon nanotubes
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DOI: 10.1002/bab.1939
Abstract: Porcine pancreas lipase (PPL) was immobilized on magnetic multiwalled carbon nanotubes successfully for the synthesis of substituted 2H‐chromenes. The catalytic activity of immobilized PPL was much higher than that of free PPL. Effects of reaction… read more here.
Keywords: immobilized magnetic; substituted chromenes; magnetic multiwalled; multiwalled carbon ... See more keywords
Synthesis of N‐Substituted Iminosugar Derivatives and Evaluation of Their Immunosuppressive Activities
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DOI: 10.1002/cmdc.201700706
Abstract: It is important to find more effective and safer immunosuppressants, because clinically used immunosuppressive agents have significant side effects. A series of N‐substituted iminosugar derivatives were designed and synthesized, and their immunosuppressive effects were evaluated… read more here.
Keywords: inhibitory effects; derivatives evaluation; substituted iminosugar; synthesis substituted ... See more keywords
Synthesis of N6‐Substituted Adenosines as Cytokinin Nucleosides
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DOI: 10.1002/cpnc.49
Abstract: This unit describes preparation of N6‐substituted adenosines (cytokinin nucleosides), a unique class of compounds with a wide spectrum of biological activities. Regioselective alkylation of N6‐acetyl‐2′,3′,5′‐tri‐O‐acetyladenosine with alkyl halides under basic conditions or alcohols under Mitsunobu… read more here.
Keywords: cytokinin; substituted adenosines; chemistry; synthesis substituted ... See more keywords
ABNO-Catalyzed Aerobic Oxidative Synthesis of 2-Substituted 4H-3,1-Benzoxazines and Quinazolines
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DOI: 10.1002/ejoc.201700384
Abstract: A new transition-metal-free 9-azabicyclo[3.3.1]nonan-N-oxyl (ABNO) catalyzed aerobic oxidative synthesis of 2-substituted 4H-3,1-benzoxazines and quinazolines has been developed through cascade reaction of aldehydes with 2-aminobenzyl alcohols and 2-aminobenzylamines, respectively. Under the optimal reaction conditions, the two… read more here.
Keywords: synthesis substituted; oxidative synthesis; abno catalyzed; aerobic oxidative ... See more keywords
Synthesis of N‐Substituted Condensed Tetrahydropyridine‐Based Enaminones via Palladium‐Catalyzed Intramolecular C–N Cross‐coupling
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DOI: 10.1002/jhet.3085
Abstract: Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, CZ 532 10 Pardubice, Czech Republic Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská… read more here.
Keywords: pardubice; chemistry; tetrahydropyridine based; synthesis substituted ... See more keywords
An Exceedingly Mild, Green Synthesis of Substituted N‐3‐diaryl‐1,8‐naphthyridin‐2‐amine Derivatives and Their Antimicrobial Activity
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DOI: 10.1002/jhet.3125
Abstract: An exceedingly and highly efficient procedure has been described for the synthesis of substituted N-3-diaryl-1,8-naphthyridin-2-amines by the reaction of 2-chloro-3-aryl-1,8-naphthyridines with various anilines in the presence of N-methyl-2-pyrrolidone and K2CO3 under thermal green solvent-free conditions.… read more here.
Keywords: synthesis substituted; exceedingly mild; substituted diaryl; activity ... See more keywords
SYNTHESIS OF N -SUBSTITUTED TETRAPROPARGYLAMINES BY CATALYTIC AMINOMETHYLATION OF Α,Ω-DIACETYLENES
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DOI: 10.1007/4807
Abstract: A catalytic method was developed for the synthesis of N-substituted tetrapropargylamines by reactions of α,ω-diacetylenes with 1,5,3-dioxazepanes, aldehydes (benzaldehydes, formaldehyde), and cyclic secondary amines. read more here.
Keywords: synthesis substituted; aminomethylation diacetylenes; catalytic aminomethylation; tetrapropargylamines catalytic ... See more keywords
SYNTHESIS OF N -SUBSTITUTED 2-AMINOMETHYL-5-METHYL-7-PHENYLOXAZOLO[5,4- b ]PYRIDINES
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DOI: 10.1007/4899
Abstract: 2-(Chloromethyl)-5-methyl-7-phenyloxazolo[5,4-b]pyridine was obtained by intramolecular cyclization based on the previously synthesized 2-chloro-N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)acetamide. The possibility of its use in the synthesis of previously unknown 2-aminomethyloxazolo[5,4-b]pyridine derivatives by nucleophilic substitution with various amines and a cyclic amide… read more here.
Keywords: methyl; substituted aminomethyl; methyl phenyloxazolo; synthesis substituted ... See more keywords
REGIO- AND DIASTEREOSELECTIVE SYNTHESIS OF N -SUBSTITUTED 2-ACYL-3-ARYL-3,5-DIHYDROFURO[3,2- c ]PYRIDIN-4(2 H )-ONES
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DOI: 10.1007/5898
Abstract: Трехкомпонентной конденсацией генерируемых in situ ацилметилидов пиридиния с ароматическими альдегидами и 4-гидрокси-6-метилпиридонами получена серия 3-арил-2-ацил-3,5-дигидрофуро[3,2- c ]пиридин-4(2 H )-онов. Реакция протекает диастереоселективно с образованием транс -изомеров и представляет собой каскадный процесс, включающий конденсацию Кнёвенагеля, карбо-реакцию… read more here.
Keywords: diastereoselective synthesis; synthesis substituted; regio diastereoselective; acyl aryl ... See more keywords
Synthesis of N-Substituted Indoles via Aqueous Ring-Closing Metathesis
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DOI: 10.1007/s10562-020-03271-3
Abstract: Abstract We report herein the synthesis of N -substituted indoles resulting from the ring-closing metathesis of indole precursors bearing N -terminal alkenes. The aqueous metathesis of the indole precursors gave good yields of N -substituted… read more here.
Keywords: metathesis; synthesis substituted; closing metathesis; substituted indoles ... See more keywords