Furo[2,3- g]thieno[2,3- e]indole: Application of an Ynamide-Based Benzannulation Strategy to the Synthesis of a Tetracyclic Heteroaromatic Compound.
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DOI: 10.1021/acs.orglett.8b02920
Abstract: The first synthesis of the tetracyclic aromatic compound furo[2,3- g]thieno[2,3- e]indole ("FTI") is described. The synthetic strategy features a photochemical benzannulation based on the reaction of an α-diazo ketone and ynamide which assembles a benzothiophene… read more here.
Keywords: thieno indole; synthesis tetracyclic; furo thieno; compound ... See more keywords
Synthesis of the Tetracyclic Framework of Polycyclic Spiro Lignan Natural Products
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DOI: 10.1021/acsomega.0c00976
Abstract: Polycyclic spiro lignans are a new family of lignan natural products recently isolated from Gymnotheca involucrata. The first synthesis of two model substrates of this rare family of natural products was achieved in six steps.… read more here.
Keywords: lignan natural; framework; natural products; synthesis tetracyclic ... See more keywords
A modular synthesis of tetracyclic meroterpenoid antibiotics
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DOI: 10.1038/s41467-017-02061-7
Abstract: Stachyflin, aureol, smenoqualone, strongylin A, and cyclosmenospongine belong to a family of tetracyclic meroterpenoids, which, by nature of their unique molecular structures and various biological properties, have attracted synthetic and medicinal chemists alike. Despite their… read more here.
Keywords: modular synthesis; meroterpenoid antibiotics; synthesis tetracyclic; synthesis ... See more keywords
Microfluidic light-driven synthesis of tetracyclic molecular architectures
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DOI: 10.3762/bjoc.14.219
Abstract: Herein we report an effective synthetic method for the direct assembly of highly functionalized tetracyclic pharmacophoric cores. Coumarins and chromones undergo diastereoselective [4 + 2] cycloaddition reactions with light-generated photoenol intermediates. The reactions occur by… read more here.
Keywords: tetracyclic molecular; synthesis tetracyclic; molecular architectures; microfluidic light ... See more keywords