The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines
Sign Up to like & getrecommendations! Published in 2022 at "Chemcatchem"
DOI: 10.1002/cctc.202201126
Abstract: Imine reductases (IREDs) are NADPH‐dependent enzymes with significant biocatalytic potential for the synthesis of primary, secondary, and tertiary chiral amines. Their applications include the reduction of cyclic imines and the reductive amination of prochiral ketones.… read more here.
Keywords: discovery imine; reductases utilisation; synthesis; synthesis tetrahydroisoquinolines ... See more keywords
Stereoselective Synthesis of Tetrahydroisoquinolines from Chiral 4-Azaocta-1,7-diynes and 4-Azaocta-1,7-enynes
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201901590
Abstract: We thank the continued financial support from the Ministerio de Economia y Competitividad (MINECO; project CTQ2014-53695-P, CTQ2014-51912-REDC, CTQ2016-81797-REDC, CTQ2017-85093-P), Ministerio de Ciencia, Innovacion y Universidades (RED2018-102387-T), FEDER, the Generalitat Valenciana (PROMETEOII/2014/017), ant the University of… read more here.
Keywords: chiral azaocta; diynes azaocta; stereoselective synthesis; synthesis tetrahydroisoquinolines ... See more keywords
Multicomponent Synthesis of Tetrahydroisoquinolines.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01159
Abstract: A multicomponent synthesis of tetrahydroisoquinolines from carboxylic acids, alkynyl ethers, and dihydroisoquinolines is described. This process features readily available starting materials, simple experimental procedures for achievement of molecule complexity, and structural diversity. The preliminary control… read more here.
Keywords: multicomponent synthesis; synthesis tetrahydroisoquinolines;