Water-Compatible Synthesis of 2-Trifluoromethyl-1,3-Dioxanes
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201801367
Abstract: A water-compatible method for the diastereoselective synthesis of 2-trifluormethyl-1,3-dioxanes is described. The reaction proceeds under mild reaction conditions using simple inorganic bases; it has a very good substrate scope and can be performed with different… read more here.
Keywords: water; water compatible; synthesis trifluoromethyl; trifluoromethyl dioxanes ... See more keywords
Copper-catalyzed tandem cyclization and vinylation for the synthesis of 2-trifluoromethyl benzofurans
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2019.109418
Abstract: Abstract A copper-catalyzed tandem cyclization and vinylation of 2-chloro-1-(2-bromoaryl)-3,3,3-trifluoropropenes with KOH has been developed for the synthesis of 2-trifluoromethyl benzofuran derivatives. The reaction involves dual C O bonds formation and hydroarylation of aryl trifluoropropynes. This… read more here.
Keywords: tandem cyclization; cyclization vinylation; catalyzed tandem; synthesis trifluoromethyl ... See more keywords
A new synthesis of 4′-trifluoromethyl-2,2′:6′,2″-terpyridine
Sign Up to like & getrecommendations! Published in 2021 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2021.04.035
Abstract: Reflux of two isomeric 3-amino-4,4,4-trifluoro-1-(2-pyridyl)but-2-en-1-one and 3-amino-1,1,1-trifluoro-4-(2-pyridyl)-but-3-en-2-one in acetic acid affords 4′-trifluoromethyl-2,2′:6′,2″-terpyridine (37%) with 1.4% admixture of 6′-trifluoromethyl-2,2′:4′,2″-terpyridine. read more here.
Keywords: trifluoromethyl; synthesis trifluoromethyl; trifluoromethyl terpyridine; new synthesis ... See more keywords
Synthesis of trifluoromethyl and trifluoroacetyl substituted dihydropyrrolizines and tetrahydroindolizines
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.151633
Abstract: Abstract The trifluoroacetic anhydride promoted cyclization of enaminones derived from proline or pipecolic acid and β-ethoxyvinyl trifluoromethyl ketone was reinvestigated. An operationally simple procedure for the selective synthesis of bicyclic trifluoromethylated pyrroles and bicyclic pyrroles… read more here.
Keywords: trifluoromethyl trifluoroacetyl; substituted dihydropyrrolizines; trifluoroacetyl substituted; synthesis trifluoromethyl ... See more keywords
Rh(III)-Catalyzed Dual C-H Activation/Cascade Annulation of Benzimidates and CF3-Imidoyl Sulfoxonium Ylides for the Synthesis of Trifluoromethyl-Decorated Benzo[de][1,8]naphthyridines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03666
Abstract: An efficient and straightforward approach for the synthesis of trifluoromethyl-decorated benzo[de][1,8]naphthyridines has been achieved via the Rh(III)-catalyzed dual C-H activation and cascade annulation of benzimidates and CF3-imidoyl sulfoxonium ylides. The novel transformation involves the formation… read more here.
Keywords: synthesis trifluoromethyl; decorated benzo; catalyzed dual; benzo naphthyridines ... See more keywords
Selectively Tunable Synthesis of α-Trifluoromethyl Ketones.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00725
Abstract: A cross-coupling of aldehydes and α-trifluoromethyl alkyl bromides was developed via dual nickel/photoredox catalysis system. A wide variety of substrates bearing a diverse set of functional groups were compatible to afford α-trifluoromethyl ketones under very… read more here.
Keywords: synthesis trifluoromethyl; selectively tunable; trifluoromethyl ketones; tunable synthesis ... See more keywords
Na2S·9H2O Enabled Defluorodisulfuration and Hydrodefluorination of Perfluorobutyl Tetralones: Synthesis of Trifluoromethyl 1,2-Dithioles.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01573
Abstract: An unprecedented defluorocyclization of perfluorobutyl tetralones with Na2S·9H2O was developed for the synthesis of trifluoromethyl 1,2-dithioles, which provided chemists novel access to biologically and pharmaceutically relevant organofluorides. Successive C(sp3)-F bond functionalization at the perfluoroalkyl chain… read more here.
Keywords: na2s 9h2o; synthesis trifluoromethyl; trifluoromethyl dithioles; perfluorobutyl tetralones ... See more keywords
Copper-Mediated Domino Cyclization/Trifluoromethylation/Deprotection with TMSCF3: Synthesis of 4-(Trifluoromethyl)pyrazoles.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03822
Abstract: A copper-mediated synthesis of 4-(trifluoromethyl)pyrazoles is described. In one step from readily accessible α,β-alkynic tosylhydrazones, a remarkable domino sequence of cyclization, trifluoromethylation, and detosylation takes place to furnish the 4-CF3 N-H pyrazole cores with good… read more here.
Keywords: copper mediated; cyclization trifluoromethylation; trifluoromethyl pyrazoles; synthesis trifluoromethyl ... See more keywords
Highly Diastereoselective Synthesis of Trifluoromethyl Indolines by Interceptive Benzylic Decarboxylative Cycloaddition of Nonvinyl, Trifluoromethyl Benzoxazinanones with Sulfur Ylides under Palladium Catalysis.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00237
Abstract: A highly diastereoselective synthesis of trifluoromethyl-substituted indolines under palladium catalysis is disclosed. The reaction proceeds by interceptive decarboxylative benzylic cycloaddition (IDBC) of nonvinyl, trifluoromethyl benzoxazinanones with sulfur ylides. The palladium-π-benzyl zwitterionic intermediates are suggested for… read more here.
Keywords: nonvinyl trifluoromethyl; diastereoselective synthesis; palladium catalysis; synthesis trifluoromethyl ... See more keywords
Synthesis of 2-(Trifluoromethyl)indoles via Domino Trifluoromethylation/Cyclization of 2-Alkynylanilines.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00509
Abstract: A new method for the synthesis of 2-(trifluoromethyl)indoles using easily accessible 2-alkynylanilines and a well-established fluoroform-derived CuCF3 reagent is described. This method utilizes a domino trifluoromethylation/cyclization strategy to construct the indole cores with no ambiguity… read more here.
Keywords: domino trifluoromethylation; trifluoromethylation cyclization; trifluoromethyl indoles; synthesis trifluoromethyl ... See more keywords
Organocatalytic Synthesis of α-Trifluoromethyl Allylboronic Acids by Enantioselective 1,2-Borotropic Migration
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c09923
Abstract: Chiral α-substituted allylboronic acids were synthesized by asymmetric homologation of alkenylboronic acids using CF3/TMS-diazomethanes in the presence of BINOL catalyst and ethanol. The chiral α-substituted allylboronic acids were reacted with aldehydes or oxidized to alcohols… read more here.
Keywords: allylboronic acids; enantioselective borotropic; synthesis trifluoromethyl; trifluoromethyl allylboronic ... See more keywords