Synthesis of Trifluoromethylated 4H-Pyran and 4H-Thiopyran via Divergent Reaction of β-CF3-1,3-Enynes with β-Ketothioamides.
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DOI: 10.1021/acs.orglett.2c03264
Abstract: A chemodivergent tandem intermolecular hydrocarbonation and intramolecular oxy- or thioheterocyclization sequence of β-CF3-1,3-enyne with β-ketothioamides (KTAs) leading to ring-trifluoromethylated 4H-pyran or 4H-thiopyran, respectively, by the combined use of AgNO3 as a catalyst and Et3N as… read more here.
Keywords: trifluoromethylated pyran; pyran thiopyran; synthesis trifluoromethylated; cf3 ... See more keywords
Photoredox Microfluidic Synthesis of Trifluoromethylated Amino Acids.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00915
Abstract: Fluorinated amino acids are a class of highly valuable building blocks that are widely employed in biological science and pharmaceutical industry for improved stability, activity, and folding property of proteins. However, the synthetic approach has… read more here.
Keywords: amino acids; photoredox microfluidic; synthesis; trifluoromethylated amino ... See more keywords
Synthesis of Trifluoromethylated Aziridines Via Photocatalytic Amination Reaction
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DOI: 10.1021/acscatal.0c04564
Abstract: Trifluoromethylated aziridines are the smallest fluorinated N-heterocycle and represent important strategic building blocks with broad application in drug discovery for the synthesis of functionali... read more here.
Keywords: aziridines via; via photocatalytic; photocatalytic amination; trifluoromethylated aziridines ... See more keywords
Enantioselective synthesis of trifluoromethylated dihydroquinoxalinones via palladium-catalyzed hydrogenation
Sign Up to like & getrecommendations! Published in 2019 at "Organic Chemistry Frontiers"
DOI: 10.1039/c8qo01361f
Abstract: A highly enantioselective palladium-catalyzed asymmetric hydrogenation of 3-(trifluoromethyl)quinoxalinones has been successfully developed, providing a general and facile access to chiral 3-(trifluoromethyl)-3,4-dihydroquinoxalinones with up to 99% ee. read more here.
Keywords: trifluoromethylated dihydroquinoxalinones; palladium catalyzed; enantioselective synthesis; synthesis trifluoromethylated ... See more keywords
Copper-catalyzed synthesis of trifluoromethylated bis(indolyl)arylmethanes from 2-arylindoles and 2,2,2-trifluoroacetohydrazide
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/c9qo01131e
Abstract: One-pot synthesis of trifluoromethylated bis(indolyl)arylmethanes through copper-catalyzed reaction of 2-arylindoles with 2,2,2-trifluoroacetohydrazide is described. This viable transformation provides a variety of 3,3′-bis(indolyl)methanes with a CF3-containing tertiary carbon center in moderate to good yields. Preliminary mechanistic… read more here.
Keywords: bis indolyl; indolyl arylmethanes; trifluoromethylated bis; arylindoles trifluoroacetohydrazide ... See more keywords
Synthesis of Trifluoromethylated B12 Derivative and Photolysis of Cobalt(III)–Trifluoromethyl Bond
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DOI: 10.1246/cl.180355
Abstract: A vitamin B12 derivative with a trifluoromethyl group as an axial ligand, heptamethyl trifluoromethylaquacobyrinate perchlorate, [[(CF3)(H2O)Cob(III)7C1ester]ClO4], is prepared and characterized by elemental analysis, 1H NMR, 19F NMR, ESI-MS, UV-vis absorption, and cyclic voltammetry. The Co–CF3… read more here.
Keywords: b12 derivative; bond; trifluoromethyl; synthesis trifluoromethylated ... See more keywords
Synthesis of Trifluoromethylated Monoterpene Amino Alcohols
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27207068
Abstract: For the first time, monoterpene trifluoromethylated β-hydroxy-benzyl-O-oximes were synthesized in 81–95% yields by nucleophilic addition of the Ruppert–Prakash reagent (TMSCF3) to the corresponding β-keto-benzyl-O-oximes based on (+)-nopinone, (−)-verbanone and (+)-camphoroquinone. Trifluoromethylation has been determined to… read more here.
Keywords: trifluoromethylated monoterpene; monoterpene; amino alcohols; benzyl oximes ... See more keywords