REGIOSELECTIVE SYNTHESIS OF 1,3,5-TRISUBSTITUTED PYRAZOLES CONTAINING AN ANTHRANILIC ACID MOTIF
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/5109
Abstract: An effective method was developed for the synthesis of 1,3,5-trisubstituted pyrazoles by using acetylenic ketones, obtained from ethyl 5-ethynylanthranilate, in reactions with substituted hydrazines and hydrazides. It was shown that the cyclization of ethyl 5-(3-aryl-3-oxopropinyl)anthranilates… read more here.
Keywords: containing anthranilic; pyrazoles containing; trisubstituted pyrazoles; synthesis trisubstituted ... See more keywords
A facile synthesis of trisubstituted allenamides by DBU-promoted isomerization of propargylamides
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152146
Abstract: Abstract Trisubstituted allenamides are synthesized by the isomerization of propargylamides with DBU. The reactions afforded a variety of substituted allenamides under simple and mild conditions. One-pot synthesis of allenamides from propargylamines, which were easily prepared… read more here.
Keywords: facile synthesis; isomerization propargylamides; trisubstituted allenamides; synthesis trisubstituted ... See more keywords
Synthesis of Trisubstituted Furans via Copper(I)-Catalyzed Strain-Driving Cycloisomerization/Annulative Fragmentation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00578
Abstract: The in situ formed furan-fused cyclobutenes via Cu(I)-catalyzed cycloisomerization of readily available allenyl ketones bearing a cyclopropyl moiety are a highly reactive and powerful species, which undergo annulative fragmentation with terminal ynones to afford a… read more here.
Keywords: synthesis trisubstituted; trisubstituted furans; strain; cycloisomerization ... See more keywords
Synthesis of Trisubstituted Oxazoles via Aryne Induced [2,3] Sigmatropic Rearrangement-Annulation Cascade.
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DOI: 10.1021/acs.orglett.2c01379
Abstract: A transition-metal-free, [2,3] sigmatropic rearrangement-annulation cascade of 2-substituted thio/amino acetonitriles with arynes allowing the synthesis of 2,4,5-trisubstituted oxazoles under mild conditions has been demonstrated. The key sulfur/nitrogen ylides were generated by the initial S/N arylation… read more here.
Keywords: synthesis trisubstituted; rearrangement annulation; annulation cascade; rearrangement ... See more keywords
Catalytic One-Pot Synthesis of Trisubstituted Allenes from Terminal Alkynes and Ketones.
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DOI: 10.1021/acs.orglett.7b02443
Abstract: An efficient one-pot synthesis of trisubstituted allenes from readily available terminal alkynes and ketones is realized. A wide range of trisubstituted allenes may be synthesized efficiently via this method. Preliminary mechanistic studies revealed that CuI… read more here.
Keywords: alkynes ketones; one pot; pot synthesis; terminal alkynes ... See more keywords
Enantioselective Synthesis of 2,2,3-Trisubstituted Indolines via Bimetallic Relay Catalysis of α-Diazoketones with Enones.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01744
Abstract: An efficient asymmetric intramolecular trapping of ammonium ylides of α-diazoketones with enones to synthesize indoline derivatives was realized. A Rh(II)/chiral N,N'-dioxide-Sc(III) complex bimetallic relay catalytic system was established. A series of optically active 2,2,3-trisubstituted indolines… read more here.
Keywords: trisubstituted indolines; synthesis trisubstituted; bimetallic relay; diazoketones enones ... See more keywords
Synthesis of Trisubstituted Alkenyl Boronic Esters from Alkenes Using the Boryl-Heck Reaction.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b02949
Abstract: The direct borylation of disubstituted alkenes is reported. These conditions allow for the conversion of a variety 1,1- and 1,2-disubstituted alkenes to trisubstituted alkenyl boronic esters with outstanding yields and excellent E/ Z selectivities. The… read more here.
Keywords: synthesis trisubstituted; boryl heck; reaction; boronic esters ... See more keywords
Cu(I)-Catalyzed stereoselective synthesis of trisubstituted Z-enol esters via interrupting the 1,3-O-transposition reaction
Sign Up to like & getrecommendations! Published in 2018 at "Organic chemistry frontiers"
DOI: 10.1039/c8qo00664d
Abstract: An efficient Cu(I)-catalyzed stereoselective synthesis of trisubstituted Z-enol esters via interrupting the 1,3-O-transposition process is reported. This method provided a convenient approach to highly functionalized Z-enol esters with mild reaction conditions and wide substrate scope. read more here.
Keywords: trisubstituted enol; esters via; stereoselective synthesis; catalyzed stereoselective ... See more keywords
A trisulfur radical anion (S3˙-) involved sulfur insertion reaction of 1,3-enynes: sulfide sources control chemoselective synthesis of 2,3,5-trisubstituted thiophenes and 3-thienyl disulfides.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc03604k
Abstract: Cascade cyclization reactions of S3˙- in situ generated from S2- with 1,3-enynes for the chemoselective synthesis of 2,3,5-trisubstituted thiophenes and 3-thienyl disulfides controlled by sulfide salts are developed. These two protocols provide new, environment-friendly and… read more here.
Keywords: thiophenes thienyl; thienyl disulfides; synthesis trisubstituted; trisubstituted thiophenes ... See more keywords
Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction
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DOI: 10.1039/d1ra01767e
Abstract: A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. read more here.
Keywords: trisubstituted imidazoles; synthesis trisubstituted; practical method; method synthesis ... See more keywords
An efficient and eco-compatible multicomponent synthesis of 2,4,5-trisubstituted imidazole derivatives using modified-silica-coated cobalt ferrite nanoparticles with tungstic acid.
Sign Up to like & getrecommendations! Published in 2023 at "Dalton transactions"
DOI: 10.1039/d2dt03021g
Abstract: The aim of this study has been to offer a method for the synthesis of 2,4,5-trisubstituted imidazole derivatives based on green chemistry principles. Therefore, a one-pot multicomponent cyclocondensation reaction through aldehyde interaction with ammonium acetate… read more here.
Keywords: synthesis trisubstituted; efficient eco; imidazole derivatives; tungstic acid ... See more keywords