MULTICOMPONENT SYNTHESIS OF UNSYMMETRICAL 5-NITROPYRIDINES
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/4746
Abstract: Reaction of 2-nitroacetophenone, furfurol, β-dicarbonyl compounds, and ammonium acetate led to 3-substituted 4-(2-furyl)-5-nitro-6-phenyl-1,4-dihydropyridines, which were oxidized with potassium nitrate in the presence of copper(II) nitrate (10 mol %), leading to the respective 5-nitro-6-phenylpyridines. The performed… read more here.
Keywords: multicomponent synthesis; chemistry; unsymmetrical nitropyridines; synthesis unsymmetrical ... See more keywords
Reductive Halogenation Reactions: Selective Synthesis of Unsymmetrical α-Haloketones.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02324
Abstract: A method for the selective synthesis of unsymmetrical α-haloketones has been developed. The key transformation is a triphenylphosphine oxide catalyzed reductive halogenation of an α,β-unsaturated ketone in which trichlorosilane is the reducing reagent and an… read more here.
Keywords: selective synthesis; reductive halogenation; synthesis unsymmetrical; unsymmetrical haloketones ... See more keywords
Synthesis of Unsymmetrical Ketones Using Chelation-Controlled Sequential Substitution of N-Triazinylamide/Weinreb Amide by Organometallic Reagents
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DOI: 10.1021/acsomega.2c06756
Abstract: N-(2,4-Dimethoxy-1,3,5-triazinyl)amide was found to exhibit similar behavior to N-methoxy-N-methylamide (Weinreb amide) but higher reactivity for nucleophilic substitution by organometallic reagents. Triazinylamide suppresses overaddition, leading to the formation of a tertiary alcohol by the chelating ability… read more here.
Keywords: substitution; unsymmetrical ketones; ketones using; organometallic reagents ... See more keywords
Chan–Lam coupling reaction of sulfamoyl azides with arylboronic acids for synthesis of unsymmetrical N-arylsulfamides
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DOI: 10.1039/c8ra09219b
Abstract: An efficient method was developed for the synthesis of unsymmetrical N-arylsulfamides using sulfamoyl azides and arylboronic acids in the presence of 10 mol% of copper chloride as the catalyst. read more here.
Keywords: azides arylboronic; arylboronic acids; synthesis unsymmetrical; sulfamoyl azides ... See more keywords
Synthesis of unsymmetrical ketones by applying visible-light benzophenone/nickel dual catalysis for direct benzylic acylation.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc01480j
Abstract: Herein, we report a dual catalytic system for the direct benzylic C-H acylation reaction furnishing a variety of unsymmetrical ketones. A benzophenone-derived photosensitizer combined with a nickel catalyst has been established as the catalytic system.… read more here.
Keywords: benzylic acylation; acylation; direct benzylic; synthesis unsymmetrical ... See more keywords
Regio- and diastereoselective synthesis of unsymmetrical 1,4-diketone-derived (Z)-monosilyl enol ethers via siloxyallylpotassium intermediates.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc07097a
Abstract: This paper describes the regio- and diastereoselective synthesis of unsymmetrical 1,4-diketone-derived (Z)-monosilyl enol ethers from 1-arylallyloxysilanes and Weinreb amides using (trimethylsilyl)methylpotassium as a base. The metalation of 1-arylallyloxysilanes to generate siloxyallylpotassiums is the key step… read more here.
Keywords: diastereoselective synthesis; unsymmetrical diketone; regio diastereoselective; diketone derived ... See more keywords
Benign synthesis of unsymmetrical arylurea derivatives using 3-substituted dioxazolones as isocyanate surrogates
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DOI: 10.1080/17518253.2020.1807616
Abstract: ABSTRACT A phosgene- and metal-free synthesis of unsymmetrical arylurea derivatives utilizing 3-substituted dioxazolones and commercially available amines has been developed. The 3-substituted dioxazolones serve as the precursors of the in situ generated isocyanate intermediates in… read more here.
Keywords: arylurea derivatives; substituted dioxazolones; synthesis unsymmetrical; unsymmetrical arylurea ... See more keywords
Mechanochemical synthesis of unsymmetrical salens for the preparation of Co–salen complexes and their evaluation as catalysts for the synthesis of α-aryloxy alcohols via asymmetric phenolic kinetic resolution of terminal epoxides
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.18.147
Abstract: In this paper, we report the mechanochemical synthesis of unsymmetrical salens using grinding and ball milling technologies, respectively, both of which were afforded in good yield. The chelating effect of the unsymmetrical salens with zinc,… read more here.
Keywords: aryloxy alcohols; terminal epoxides; unsymmetrical salens; synthesis unsymmetrical ... See more keywords