Characterization of Histidine Functionalization and Its Timing in the Biosynthesis of Ribosomally Synthesized and Posttranslationally Modified Thioamitides.
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DOI: 10.1021/jacs.1c11669
Abstract: Thioamitides are ribosomally synthesized and posttranslationally modified peptide (RiPP) natural products that hold great potential in anticancer drug development. Members in this RiPP family feature a thioamidated peptidyl chain conjugated with a macrocyclic ring system… read more here.
Keywords: biosynthesis; posttranslationally modified; ribosomally synthesized; functionalization ... See more keywords