Involvement of a Noncanonical Polyketide Synthase–Nonribosomal Peptide Synthetase Hybrid in the Biosynthesis of Sterol-C4-methyl Oxidase Inhibitor PF1163A
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DOI: 10.1021/acs.orglett.4c03675
Abstract: PF1163A (1) is a fungal metabolite that inhibits sterol-C4-methyl oxidase. In this study, we identified the biosynthetic gene cluster of 1 and elucidated its biosynthetic pathway through heterologous expression experiments. Polyketide synthase–nonribosomal synthetase hybrid PfaA,… read more here.
Keywords: polyketide synthase; synthase nonribosomal; methyl oxidase; synthetase hybrid ... See more keywords