Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.039
Abstract: Phytoestrogens are class of natural compounds that shares structural similarity with estrogen and has the capacity to alter the fertilization in mammals. Till early 1990s, the natural phytoestrogens as well as their synthetic analogues were… read more here.
Keywords: synthetic analogues; substrate mimic; class; mimic inhibitors ... See more keywords
Asymmetric Total Synthesis of (+)-Phainanoid A and Biological Evaluation of the Natural Product and Its Synthetic Analogues.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13889
Abstract: Here, we report our detailed efforts toward the synthesis of phainanoids, a novel class of dammarane-type triterpenoids with potent immunosuppressive activities and unique structural features. Systematic model studies have been carried out, and efficient approaches… read more here.
Keywords: phainanoid; synthesis phainanoid; synthesis; synthetic analogues ... See more keywords
A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02411j
Abstract: We demonstrate a recycling system for synthetic nicotinamide cofactor analogues using a soluble hydrogenase with turnover number of >1000 for reduction of the cofactor analogues by H2. Coupling this system to an ene reductase, we… read more here.
Keywords: driven biocatalytic; hydrogen driven; synthetic analogues; biocatalytic approach ... See more keywords
Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in Trypanosoma cruzi
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13030663
Abstract: Chagas disease is an endemic tropical disease caused by the protozoan Trypanosoma cruzi, which affects around 7 million people worldwide, mostly in development countries. The treatment relies on only two available drugs, with severe adverse… read more here.
Keywords: gibbilimbol induce; analogues gibbilimbol; trypanosoma cruzi; synthetic analogues ... See more keywords
New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15030339
Abstract: NAD+-dependent deacetylase SIRT1 regulates many different biological processes, thus being involved in pathogenic conditions such as metabolic diseases, neurogenerative disorders and cancer. Notably, experimental evidence underlined that the activation of SIRT1 had promising cardioprotective effects.… read more here.
Keywords: analogues natural; synthetic analogues; new synthetic; polyphenols sirtuin ... See more keywords