A Single‐Framework Synthetic Antibody Library Containing a Combination of Canonical and Variable Complementarity‐Determining Regions
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700279
Abstract: Synthetic antibody libraries have been used to generate antibodies with favorable biophysical and pharmacological properties. Here, we describe the design, construction, and validation of a phage‐displayed antigen‐binding fragment (Fab) library built on a modified trastuzumab… read more here.
Keywords: complementarity determining; framework; antibody; determining regions ... See more keywords
Synthetic antibody mimics for the inhibition of protein-ligand interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.07.001
Abstract: The rational/structure-based design and/or combinatorial development of molecules capable of selectively binding to a protein, represents a promising strategy for a range of biomedical applications, in particular the inhibition of disease-associated protein-ligand interactions. The design… read more here.
Keywords: protein; antibody; ligand interactions; antibody mimics ... See more keywords
Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.11.008
Abstract: Successful antibody development requires both functional binding and desirable biophysical characteristics. In the current study, we analyze the causes of one hurdle to clinical development, off-target reactivity, or nonspecificity. We used a high-throughput nonspecificity assay… read more here.
Keywords: antibody; nonspecificity; motifs synthetic; reduction nonspecificity ... See more keywords
Synthetic antibody binders detect distinct cellular states of Chromosome Passenger Complex proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167602
Abstract: High performance affinity reagents are essential tools to enable biologists to profile the cellular location and composition of macromolecular complexes undergoing dynamic reorganization. To support further development of such tools, we have assembled a high-throughput… read more here.
Keywords: antibody binders; cpc; binders detect; synthetic antibody ... See more keywords
Abiotic Synthetic Antibody Inhibitor with Broad-Spectrum Neutralization and Antiviral Efficacy against Escaping SARS-CoV-2 Variants
Sign Up to like & getrecommendations! Published in 2023 at "ACS Nano"
DOI: 10.1021/acsnano.3c02050
Abstract: The rapid emergence and spread of vaccine/antibody-escaping variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed serious challenges to our efforts in combating corona virus disease 2019 (COVID-19) pandemic. A potent and broad-spectrum… read more here.
Keywords: synthetic antibody; abiotic synthetic; inhibitor; sars cov ... See more keywords