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   Articles with "synthetic cells" as a keyword



Functional Integration of Synthetic Cells into 3D Microfluidic Devices for Artificial Organ‐On‐Chip Technologies

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202303334

Abstract: Microfluidics plays a pivotal role in organ‐on‐chip technologies and in the study of synthetic cells, especially in the development and analysis of artificial cell models. However, approaches that use synthetic cells as integral functional components… read more here.

Keywords: synthetic cells; microfluidic devices; chip; integration synthetic ... See more keywords

Dendrimersome Synthetic Cells Harbor Cell Division Machinery of Bacteria

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recommendations! Published in 2022 at "Advanced Materials"

DOI: 10.1002/adma.202202364

Abstract: The integration of active cell machinery with synthetic building blocks is the bridge toward developing synthetic cells with biological functions and beyond. Self‐replication is one of the most important tasks of living systems, and various… read more here.

Keywords: cell; cell division; division machinery; machinery ... See more keywords

Towards Synthetic Cells with Self-Producing Energy.

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recommendations! Published in 2024 at "ChemPlusChem"

DOI: 10.1002/cplu.202400138

Abstract: Autonomous generation of energy, specifically adenosine triphosphate (ATP), is critical for sustaining the engineered functionalities of synthetic cells constructed from the bottom-up. In this mini-review, we categorize studies on ATP-producing synthetic cells into three different… read more here.

Keywords: cells self; energy; synthetic cells; self producing ... See more keywords

Synthetic cells in biomedical applications.

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recommendations! Published in 2021 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"

DOI: 10.1002/wnan.1761

Abstract: Synthetic cells are engineered vesicles that can mimic one or more salient features of life. These features include directed localization, sense-and-respond behavior, gene expression, metabolism, and high stability. In nanomedicine, many of these features are… read more here.

Keywords: cells biomedical; synthetic cells; biology; biomedical applications ... See more keywords

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells.

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recommendations! Published in 2025 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.5c00043

Abstract: Synthetic cells are a rapidly maturing platform with emerging applications in biomedicine and biotechnology. The specific novelty of this work is that we develop synthetic cells that respond to an extracellular stimulus by performing the… read more here.

Keywords: transmembrane activation; receptor mediated; protein folding; synthetic cells ... See more keywords
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Bottom-Up Assembly of Synthetic Cells with a DNA Cytoskeleton.

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recommendations! Published in 2022 at "ACS nano"

DOI: 10.1021/acsnano.1c10703

Abstract: Cytoskeletal elements, like actin and myosin, have been reconstituted inside lipid vesicles toward the vision to reconstruct cells from the bottom up. Here, we realize the de novo assembly of entirely artificial DNA-based cytoskeletons with… read more here.

Keywords: assembly synthetic; cells dna; dna; bottom assembly ... See more keywords

Programmable Fusion and Differentiation of Synthetic Minimal Cells.

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recommendations! Published in 2022 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.1c00519

Abstract: Synthetic cells can mimic the intricate complexities of live cells, while mitigating the level of noise that is present natural systems; however, many crucial processes still need to be demonstrated in synthetic cells to use… read more here.

Keywords: programmable fusion; synthetic cells; fusion differentiation; biology ... See more keywords

Actinosomes: Condensate-Templated Containers for Engineering Synthetic Cells

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recommendations! Published in 2022 at "ACS Synthetic Biology"

DOI: 10.1021/acssynbio.2c00290

Abstract: Engineering synthetic cells has a broad appeal, from understanding living cells to designing novel biomaterials for therapeutics, biosensing, and hybrid interfaces. A key prerequisite to creating synthetic cells is a three-dimensional container capable of orchestrating… read more here.

Keywords: templated containers; condensate templated; engineering synthetic; actinosomes condensate ... See more keywords

Imaging Flow Cytometry for High-Throughput Phenotyping of Synthetic Cells.

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recommendations! Published in 2023 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.3c00074

Abstract: The reconstitution of basic cellular functions in micrometer-sized liposomes has led to a surge of interest in the construction of synthetic cells. Microscopy and flow cytometry are powerful tools for characterizing biological processes in liposomes… read more here.

Keywords: imaging flow; flow cytometry; microscopy; high throughput ... See more keywords
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Orthogonal Light-Activated DNA for Patterned Biocomputing within Synthetic Cells

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recommendations! Published in 2023 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.3c02350

Abstract: Cell-free gene expression is a vital research tool to study biological systems in defined minimal environments and has promising applications in biotechnology. Developing methods to control DNA templates for cell-free expression will be important for… read more here.

Keywords: activated dna; cell free; light; light activated ... See more keywords

Adaptive metal ion transport and metalloregulation-driven differentiation in pluripotent synthetic cells

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recommendations! Published in 2024 at "Nature Chemistry"

DOI: 10.1038/s41557-024-01682-y

Abstract: Pluripotent cells can yield different cell types determined by the specific sequence of differentiation signals that they encounter as the cell activates or deactivates functions and retains memory of previous inputs. Here, we achieved pluripotency… read more here.

Keywords: transport; metal; synthetic cells; metal ion ... See more keywords